Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Co-occurrence of infantile hypertrophic pyloric stenosis and congenital heart defects: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Extreme neonatal hyperbilirubinemia, acute bilirubin encephalopathy, and kernicterus spectrum disorder in children with galactosemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Total brain, cortical and white matter volumes in children previously treated with glucocorticoids

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Anogenital distance as a phenotypic signature through infancy

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Anthropometry, DXA, and leptin reflect subcutaneous but not visceral abdominal adipose tissue on MRI in 197 healthy adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Bjørn Andresen
  • Agnese De Carli
  • Monica Fumagalli
  • Martina Giovannella
  • Turgut Durduran
  • Udo Michael Weigel
  • Davide Contini
  • Lorenzo Spinelli
  • Alessandro Torricelli
  • Gorm Greisen
View graph of relations

BACKGROUND: The BabyLux device is a prototype optical neuro-monitor of cerebral oxygenation and blood flow for neonatology integrating time-resolved reflectance spectroscopy and diffuse correlation spectroscopy.

METHODS: Here we report the variability of six consecutive 30 s measurements performed in 27 healthy term infants at rest. Poor data quality excluded four infants.

RESULTS: Mean cerebral oxygenation was 59.6 ± 8.0%, with intra-subject standard deviation of 3.4%, that is, coefficient of variation (CV) of 5.7%. The inter-subject CV was 13.5%. Mean blood flow index was 2.7 × 10-8 ± 1.56 × 10-8 (cm2/s), with intra-subject CV of 27% and inter-subject CV of 56%. The variability in blood flow index was not reduced by the use of individual measures of tissue scattering, nor accompanied by a parallel variability in cerebral oxygenation.

CONCLUSION: The intra-subject variability for cerebral oxygenation variability was improved compared to spatially resolved spectroscopy devices, while for the blood flow index it was comparable to that of other modalities for estimating cerebral blood flow in newborn infants. Most importantly, the simultaneous measurement of oxygenation and flow allows for interpretation of the high inter-subject variability of cerebral blood flow as being due to error of measurement rather than to physiological instability.

Original languageEnglish
JournalPediatric Research
Volume86
Issue number4
Pages (from-to)515-521
Number of pages7
ISSN0031-3998
DOIs
Publication statusPublished - Oct 2019

ID: 58060983