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Rigshospitalet - a part of Copenhagen University Hospital
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Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers

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BACKGROUND: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP modulates nociceptive processing in the brain. To elucidate this we recorded blood-oxygenation-level-dependent (BOLD) signals in the brain by functional MRI after infusion of CGRP in a double-blind placebo-controlled crossover study of 27 healthy volunteers. BOLD-signals were recorded in response to noxious heat stimuli in the V1-area of the trigeminal nerve. In addition, we measured BOLD-signals after injection of sumatriptan (5-HT1B/1D antagonist).

RESULTS: Brain activation to noxious heat stimuli following CGRP infusion compared to baseline resulted in increased BOLD-signal in insula and brainstem, and decreased BOLD-signal in the caudate nuclei, thalamus and cingulate cortex. Sumatriptan injection reversed these changes.

CONCLUSION: The changes in BOLD-signals in the brain after CGRP infusion suggests that systemic CGRP modulates nociceptive transmission in the trigeminal pain pathways in response to noxious heat stimuli.

Original languageEnglish
JournalP L o S One
Volume11
Issue number3
Pages (from-to)e0150334
ISSN1932-6203
DOIs
Publication statusPublished - 2016

    Research areas

  • Adult, Brain, Calcitonin Gene-Related Peptide, Female, Healthy Volunteers, Hot Temperature, Humans, Magnetic Resonance Imaging, Male, Nociception, Placebos, Young Adult, Journal Article, Research Support, Non-U.S. Gov't

ID: 49697455