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Rigshospitalet - a part of Copenhagen University Hospital
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Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment

Research output: Contribution to journalReviewResearchpeer-review

  1. Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache

    Research output: Contribution to journalReviewResearchpeer-review

  2. Postictal inhibition of the somatosensory cortex

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Post-traumatic headache: epidemiology and pathophysiological insights

    Research output: Contribution to journalReviewResearchpeer-review

  2. Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  3. CGRP in Human Models of Migraine

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  4. CGRP in human models of primary headaches

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. PACAP38 in human models of primary headaches

    Research output: Contribution to journalJournal articleResearchpeer-review

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Calcitonin gene-related peptide (CGRP) is a key signaling molecule involved in migraine pathophysiology. Efficacy of CGRP monoclonal antibodies and antagonists in migraine treatment has fueled an increasing interest in the prospect of treating cluster headache (CH) with CGRP antagonism. The exact role of CGRP and its mechanism of action in CH have not been fully clarified. A search for original studies and randomized controlled trials (RCTs) published in English was performed in PubMed and in ClinicalTrials.gov . The search term used was "cluster headache and calcitonin gene related peptide" and "primary headaches and calcitonin gene related peptide." Reference lists of identified articles were also searched for additional relevant papers. Human experimental studies have reported elevated plasma CGRP levels during both spontaneous and glyceryl trinitrate-induced cluster attacks. CGRP may play an important role in cluster headache pathophysiology. More refined human studies are warranted with regard to assay validation and using larger sample sizes. The results from RCTs may reveal the therapeutic potential of CGRP monoclonal antibodies and antagonists for cluster headache treatment.

Original languageEnglish
JournalNeurological Sciences
Volume38
Issue number12
Pages (from-to)2089-2093
Number of pages5
ISSN1590-1874
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article, Review

ID: 52767692