Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Burden of sudden cardiac death in persons aged 1 to 49 years: nationwide study in denmark

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Right Ventricular Dysfunction and the Effect of Defibrillator Implantation in Patients With Nonischemic Systolic Heart Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Nationwide Study of Sudden Cardiac Death in People With Congenital Heart Defects Aged 0 to 35 Years

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca(2+)-Activated K(+) Channels in Pigs

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Electrocardiographic Preexcitation and Risk of Cardiovascular Morbidity and Mortality: Results From the Copenhagen ECG Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Aetiologies and temporal trends of atrioventricular block in young patients: a 20-year nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Partial Oral Therapy for Osteomyelitis and Endocarditis. Reply

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. In-hospital metabolite changes in infective endocarditis-a longitudinal 1H NMR-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background- Knowledge of the burden and causes of sudden cardiac death (SCD) is sparse in persons aged <50 years; better understanding is needed to lower the risk of SCD. The aim of this study was to report SCD incidence rates and autopsy findings in persons aged 1 to 49 years. Methods and Results- All deaths in persons aged 1 to 49 years were included in 2007 to 2009. Death certificates were reviewed by 2 physicians. History of previous admissions to hospital was assessed, and discharge summaries were read. Sudden unexpected death cases were identified and autopsy reports were collected. In the 3-year study period, there were 7849 deaths of which we identified 893 (11%) SCD cases. The annual incidence rate per 100 000 persons increased from 2.3 (95% confidence interval, 2.0-2.7) to 21.7 (95% confidence interval, 20.2-23.4) in persons aged 1 to 35 and 36 to 49 years, respectively. Coronary artery disease was the most common cause of death and was found in 158 (36%) autopsied cases, followed by 135 (31%) cases of sudden unexplained death. Conclusions- In a nationwide cohort of persons aged <50 years, the annual incidence rate of SCD was ≈10× higher in persons aged 36 to 49 years than in persons aged 1 to 35 years. Notably, coronary artery disease was the most common cause of SCD, followed by unexplained deaths. These findings may help in developing strategies to prevent SCD in the future.

Original languageEnglish
JournalCirculation. Arrhythmia and Electrophysiology
Volume7
Issue number2
Pages (from-to)205-11
Number of pages7
ISSN1941-3149
DOIs
Publication statusPublished - 1 Apr 2014

ID: 44293594