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Rigshospitalet - a part of Copenhagen University Hospital
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Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

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  1. The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

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  2. The environmental occurrence of Pseudomonas aeruginosa

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  3. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

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  4. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

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  5. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

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BACKGROUND: Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer-right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.

CASE PRESENTATION: Colonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.

CONCLUSIONS: To our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

Original languageEnglish
JournalClinical and Translational Medicine
Volume7
Issue number1
Pages (from-to)30
ISSN2001-1326
DOIs
Publication statusPublished - 17 Sep 2018

ID: 55269155