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Rigshospitalet - a part of Copenhagen University Hospital
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Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

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  1. In-vivo gentamicin susceptibility test for prevention of bacterial biofilms in bone tissue and on implants

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  2. UV light assisted antibiotics for eradication of in vitro biofilms

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  3. Biofilm formation - what we can learn from recent developments

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  4. The use of fluorescent staining techniques for microscopic investigation of polymorphonuclear leukocytes and bacteria

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  5. Implants induce a new niche for microbiomes

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BACKGROUND: Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer-right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.

CASE PRESENTATION: Colonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.

CONCLUSIONS: To our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

Original languageEnglish
JournalClinical and Translational Medicine
Volume7
Issue number1
Pages (from-to)30
ISSN2001-1326
DOIs
Publication statusPublished - 17 Sep 2018

ID: 55269155