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Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial

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Jensen, SK, Jensen, TM, Birk, NM, Stensballe, LG, Benn, CS, Jensen, KJ, Pryds, O, Jeppesen, DL & Nissen, TN 2020, 'Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial', Vaccine, vol. 38, no. 11, pp. 2449-2455. https://doi.org/10.1016/j.vaccine.2020.02.006

APA

Jensen, S. K., Jensen, T. M., Birk, N. M., Stensballe, L. G., Benn, C. S., Jensen, K. J., Pryds, O., Jeppesen, D. L., & Nissen, T. N. (2020). Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial. Vaccine, 38(11), 2449-2455. https://doi.org/10.1016/j.vaccine.2020.02.006

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Author

Jensen, Signe Kjeldgaard ; Jensen, Trine Mølbæk ; Birk, Nina Marie ; Stensballe, Lone Graff ; Benn, Christine Stabell ; Jensen, Kristoffer Jarlov ; Pryds, Ole ; Jeppesen, Dorthe Lisbeth ; Nissen, Thomas Nørrelykke. / Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial. In: Vaccine. 2020 ; Vol. 38, No. 11. pp. 2449-2455.

Bibtex

@article{97a4b6863eeb4230abf6fe23bf777e4d,
title = "Bacille Calmette-Gu{\'e}rin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial",
abstract = "BACKGROUND: The Bacille Calmette-Gu{\'e}rin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants.METHOD: The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (109 cells/L)) measured in peripheral blood.RESULTS: Overall, we found no effect of BCG on differential WBC counts at any time point.CONCLUSION: BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.",
keywords = "Bacillus Calmette-Gu{\'e}rin, Heterologous immunity, Infants, Non-specific effects, Trained innate immunity, Vaccination, White blood cell differential count",
author = "Jensen, {Signe Kjeldgaard} and Jensen, {Trine M{\o}lb{\ae}k} and Birk, {Nina Marie} and Stensballe, {Lone Graff} and Benn, {Christine Stabell} and Jensen, {Kristoffer Jarlov} and Ole Pryds and Jeppesen, {Dorthe Lisbeth} and Nissen, {Thomas N{\o}rrelykke}",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = mar,
day = "4",
doi = "10.1016/j.vaccine.2020.02.006",
language = "English",
volume = "38",
pages = "2449--2455",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial

AU - Jensen, Signe Kjeldgaard

AU - Jensen, Trine Mølbæk

AU - Birk, Nina Marie

AU - Stensballe, Lone Graff

AU - Benn, Christine Stabell

AU - Jensen, Kristoffer Jarlov

AU - Pryds, Ole

AU - Jeppesen, Dorthe Lisbeth

AU - Nissen, Thomas Nørrelykke

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/3/4

Y1 - 2020/3/4

N2 - BACKGROUND: The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants.METHOD: The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (109 cells/L)) measured in peripheral blood.RESULTS: Overall, we found no effect of BCG on differential WBC counts at any time point.CONCLUSION: BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.

AB - BACKGROUND: The Bacille Calmette-Guérin (BCG) vaccine against tuberculosis (TB) may have beneficial non-specific effects (NSEs) beyond the protection against TB. This may be related to modifications of the innate immune system. We investigated the effect of BCG at birth on differential white blood cell (WBC) count in healthy, Danish infants.METHOD: The Danish Calmette Study randomised newborns to BCG at birth (Danish strain 1331, Statens Serum Institut) or no intervention. A sub-group of infants had blood samples collected 4 days after randomisation (n = 161), and at age 3 months (n = 152) and 13 months (n = 300). We evaluated the effect of BCG on WBC differential count (total leucocytes, lymphocytes, monocytes, eosinophil, neutrophil and basophil granulocytes (109 cells/L)) measured in peripheral blood.RESULTS: Overall, we found no effect of BCG on differential WBC counts at any time point.CONCLUSION: BCG at birth did not affect WBC count in our cohort of healthy, Danish infants.

KW - Bacillus Calmette-Guérin

KW - Heterologous immunity

KW - Infants

KW - Non-specific effects

KW - Trained innate immunity

KW - Vaccination

KW - White blood cell differential count

UR - http://www.scopus.com/inward/record.url?scp=85079178800&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2020.02.006

DO - 10.1016/j.vaccine.2020.02.006

M3 - Journal article

C2 - 32057570

VL - 38

SP - 2449

EP - 2455

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 11

ER -

ID: 59348088