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Rigshospitalet - a part of Copenhagen University Hospital
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Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy

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Theoretically, repeated sampling of free β-human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation.
Original languageEnglish
JournalClinical Chemistry and Laboratory Medicine
Volume51
Issue number9
Pages (from-to)1781-8
Number of pages8
ISSN1434-6621
DOIs
Publication statusPublished - Sep 2013

ID: 42223339