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Associations between serum L-arginine and ficolins in the early phase of acute ischemic stroke - A pilot study

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  • Tihamer Molnar
  • Dorottya Csuka
  • Gabriella Pusch
  • Lajos Nagy
  • Peter Garred
  • Zsolt Illes
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INTRODUCTION: Activation of both the L-arginine and the lectin pathway contributes to the pathophysiology and the outcome of acute ischemic stroke (AIS). However, the interplay between the two systems has not yet been examined.

METHODS: A total of 44 patients with AIS were recruited into this study. Serial measurement of serum L-arginine, asymmetric and symmetric dimethylarginine (ADMA, SDMA), and hsCRP, ficolin-2, ficolin-3, MAP-1, MASP-3 and mannose-binding lectin (MBL) were analyzed within 6 h after onset of stroke and 72 h later. Outcomes were assessed as National Institutes of Health Stroke Scale (NIHSS) worsening by 24 h, poststroke infection, and death by 1 month.

RESULTS: In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively). Significantly lower ficolin-3 and MASP-3 levels were found at 72 h in patients, who developed post-stroke infection after day 4, when compared to patients without post-stroke infections (p=0.03 and p=0.009). At 72 hours, ficolin-3 levels negatively correlated with S100B (p=0.01). Ficolin-3 at 72 post-stroke hours remained an independent predictor of post-stroke infection, while only hsCRP was an independent predictor of 30-day mortality.

CONCLUSION: Early consumption of ficolin-3 is associated with complications such as post-stroke infections. In the hyperacute phase of AIS, the positive correlation between ficolins and the NO donor L-arginine may reflect the protective role of L-arginine presumably by improving the cerebral microcirculation in a prothrombotic environment induced by complement activation.

Original languageEnglish
JournalJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Volume29
Issue number8
Pages (from-to)104951
ISSN1052-3057
DOIs
Publication statusPublished - Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

    Research areas

  • Aged, Aged, 80 and over, Arginine/blood, Biomarkers/blood, Brain Ischemia/blood, Communicable Diseases/blood, Female, Humans, Lectins/blood, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Prognosis, Risk Factors, Stroke/blood, Time Factors, Ficolin, Ischemic stroke, L-arginine, Infection, Mannose- binding lectin, Outcome

ID: 61698418