Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Association of the NOS3 intron-4 VNTR polymorphism with aneurysmal subarachnoid hemorrhage

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Clinical and histopathological predictors of outcome in malignant meningioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. WHO grade I meningiomas: classification-tree for prognostic factors of survival

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Skull base versus non-skull base meningioma surgery in the elderly

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Meningiomas: skull base versus non-skull base

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Measurement of peripheral arterial tonometry in patients with diabetic foot ulcers during courses of hyperbaric oxygen treatment

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The age-related reduction in cerebral blood flow affects vertebral artery more than internal carotid artery blood flow

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Electro convulsive therapy: Modification of its effect on the autonomic nervous system using anti-cholinergic drugs

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Potential metabolic markers in glaucoma and their regulation in response to hypoxia

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECT: The nitric oxide system has been linked to the pathogenesis of aneurysmal subarachnoid hemorrhage (SAH). The authors performed a case-control study to investigate the association between SAH and common genetic variants within the endothelial nitric oxide synthase gene (NOS3).

METHODS: Three hundred thirty-three Caucasian SAH patients and 498 controls were genotyped for the -922A > G (rs 1800779), -786T > C (rs2070744), and 894G > T (rs1799983) single nucleotide polymorphisms and the intron-4 27-bp variable number of tandem repeats polymorphism (27-bp-VNTR).

RESULTS: The b/b (5 repeats) genotype of the 27-bp-VNTR was overrepresented in cases (77%) versus controls (69%) (p = 0.02). In male patients the b/b genotype was found in 85% compared with 67% in male controls, whereas in women, the frequencies were 73% and 72%, respectively. This corresponds to an odds ratio of 2.8 (95% CI 1.5-5.6, p = 0.0005) for SAH in men with the b/b genotype versus men with a/b or a/a. In women, no such association was found (OR 1.1, 95% CI 0.7-1.6, p = 0.76). Stepwise logistic regression including arterial hypertension, smoking, sex, and age with interactions yielded similar effect estimates of the 27-bp-VNTR. Haplotype analysis revealed that no single haplotype containing the b-allele was responsible for the observed genotype effect.

CONCLUSIONS: The authors' results suggest that the NOS3 27-bp-VNTR b/b genotype independent of other risk factors act in concert with male sex to substantially increase risk of SAH. This effect is not mediated by any single NOS3 haplotype.

Original languageEnglish
JournalJournal of Neurosurgery
Volume121
Issue number3
Pages (from-to)587-92
Number of pages6
ISSN0022-3085
DOIs
Publication statusPublished - Sep 2014

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Case-Control Studies, Female, Genotype, Haplotypes, Humans, Introns, Logistic Models, Male, Middle Aged, Nitric Oxide Synthase Type III, Polymorphism, Single Nucleotide, Sex Factors, Subarachnoid Hemorrhage, Tandem Repeat Sequences, Young Adult

ID: 44953225