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Rigshospitalet - a part of Copenhagen University Hospital
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Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study

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  5. Data Resource Profile: Committee of Nordic Assisted Reproductive Technology and Safety (CoNARTaS) cohort

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  1. Noncoding RNA (ncRNA) Profile Association with Patient Outcome in Epithelial Ovarian Cancer Cases

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  2. Postoperative mobilisation as an indicator for the quality of surgical nursing care

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  3. Exploring international differences in ovarian cancer treatment: a comparison of clinical practice guidelines and patterns of care

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  4. Ovariecancerbehandling i Danmark

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  • Jue-Sheng Ong
  • Liang-Dar Hwang
  • Gabriel Cuellar-Partida
  • Nicholas G Martin
  • Georgia Chenevix-Trench
  • Michael C J Quinn
  • Marilyn C Cornelis
  • Puya Gharahkhani
  • Penelope M Webb
  • Stuart MacGregor
  • Ovarian Cancer Association Consortium
  • Claus K. Høgdall (Member of study group)
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Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.

Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator.

Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases.

Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

Original languageEnglish
JournalInternational Journal of Epidemiology
Volume47
Issue number2
Pages (from-to)450-459
ISSN0300-5771
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 52205555