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Artificial neural networks improve early outcome prediction and risk classification in out-of-hospital cardiac arrest patients admitted to intensive care

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  3. Copeptin as a marker of outcome after cardiac arrest: a sub-study of the TTM trial

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  • Jesper Johnsson
  • Ola Björnsson
  • Peder Andersson
  • Andreas Jakobsson
  • Tobias Cronberg
  • Gisela Lilja
  • Hans Friberg
  • Christian Hassager
  • Jesper Kjaergard
  • Matt Wise
  • Niklas Nielsen
  • Attila Frigyesi
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BACKGROUND: Pre-hospital circumstances, cardiac arrest characteristics, comorbidities and clinical status on admission are strongly associated with outcome after out-of-hospital cardiac arrest (OHCA). Early prediction of outcome may inform prognosis, tailor therapy and help in interpreting the intervention effect in heterogenous clinical trials. This study aimed to create a model for early prediction of outcome by artificial neural networks (ANN) and use this model to investigate intervention effects on classes of illness severity in cardiac arrest patients treated with targeted temperature management (TTM).

METHODS: Using the cohort of the TTM trial, we performed a post hoc analysis of 932 unconscious patients from 36 centres with OHCA of a presumed cardiac cause. The patient outcome was the functional outcome, including survival at 180 days follow-up using a dichotomised Cerebral Performance Category (CPC) scale with good functional outcome defined as CPC 1-2 and poor functional outcome defined as CPC 3-5. Outcome prediction and severity class assignment were performed using a supervised machine learning model based on ANN.

RESULTS: The outcome was predicted with an area under the receiver operating characteristic curve (AUC) of 0.891 using 54 clinical variables available on admission to hospital, categorised as background, pre-hospital and admission data. Corresponding models using background, pre-hospital or admission variables separately had inferior prediction performance. When comparing the ANN model with a logistic regression-based model on the same cohort, the ANN model performed significantly better (p = 0.029). A simplified ANN model showed promising performance with an AUC above 0.852 when using three variables only: age, time to ROSC and first monitored rhythm. The ANN-stratified analyses showed similar intervention effect of TTM to 33 °C or 36 °C in predefined classes with different risk of a poor outcome.

CONCLUSION: A supervised machine learning model using ANN predicted neurological recovery, including survival excellently, and outperformed a conventional model based on logistic regression. Among the data available at the time of hospitalisation, factors related to the pre-hospital setting carried most information. ANN may be used to stratify a heterogenous trial population in risk classes and help determine intervention effects across subgroups.

Original languageEnglish
Article number474
JournalCritical Care
Volume24
Issue number1
Pages (from-to)474
ISSN1466-609X
DOIs
Publication statusPublished - 30 Jul 2020

    Research areas

  • Aged, Critical Care, Female, Hospitalization, Humans, Hypothermia, Induced, Male, Middle Aged, Neural Networks, Computer, Out-of-Hospital Cardiac Arrest/therapy, Prognosis, ROC Curve, Reproducibility of Results, Risk Assessment, Intensive care, Artificial neural networks, Prediction, Critical care, Prognostication, Machine learning, Out-of-hospital cardiac arrest, Artificial intelligence, Cerebral performance category

ID: 62054048