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Rigshospitalet - a part of Copenhagen University Hospital
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Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system

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  1. Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 promote the transendothelial transport of High-Density Lipoprotein

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  2. Increased plasma apoM levels impair triglyceride turnover in mice

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  3. Oral pre‑treatment with thiocyanate (SCN−) protects against myocardial ischaemia–reperfusion injury in rats

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  4. Apolipoprotein M - a marker or an active player in type II diabetes?

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Apolipoprotein M (apoM) is a member of the lipocalin superfamily and is predominantly associated with high-density lipoprotein (HDL). It was found that apoM is the chaperon to the bioactive sphingolipid, sphingosine-1-phosphate (S1P). Several studies have since contributed to expand the knowledge on apoM, S1P, and the apoM/S1P-complex in cardiovascular diseases. For instance, the HDL-bound apoM/S1P complex serves as a bridge between HDL and endothelial cells, maintaining a healthy endothelial barrier. Evidence indicates, however, that the apoM/S1P complex may has both protective and harmful effects on the cardiovascular system, which suggests the need for more research to understand the interplay between these molecules. This review aims to shed light on the most recent findings on apoM/S1P-signaling and its impact on endothelial dysfunction, inflammation, and cardiovascular diseases. Finally, it will be discussed whether drugs that target apoM and/or S1P-signaling may be beneficial to patients with cardiovascular and inflammatory diseases.

Original languageEnglish
JournalAtherosclerosis
Volume334
Pages (from-to)76-84
Number of pages9
ISSN0021-9150
DOIs
Publication statusPublished - Oct 2021

    Research areas

  • Apolipoprotein M, Cardiovascular disease, Endothelial dysfunction, Inflammation, Lipid metabolism, Sphingosine-1-phosphate

ID: 67567835