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Rigshospitalet - a part of Copenhagen University Hospital
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Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

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  • Tauseef A Khan
  • Tina Shah
  • David Prieto
  • Weili Zhang
  • Jackie Price
  • Gerald R Fowkes
  • Jackie Cooper
  • Philippa J Talmud
  • Steve E Humphries
  • Johan Sundstrom
  • Jaroslav A Hubacek
  • Shah Ebrahim
  • Debbie A Lawlor
  • Yoav Ben-Shlomo
  • Mohammad R Abdollahi
  • Arjen J C Slooter
  • Zoltan Szolnoki
  • Manjinder Sandhu
  • Nicholas Wareham
  • Ruth Frikke-Schmidt
  • Anne Tybjærg-Hansen
  • Gerda Fillenbaum
  • Bastiaan T Heijmans
  • Tomohiro Katsuya
  • Grazyna Gromadzka
  • Andrew Singleton
  • Luigi Ferrucci
  • John Hardy
  • Bradford Worrall
  • Stephen S Rich
  • Mar Matarin
  • John Whittaker
  • Tom R Gaunt
  • Peter Whincup
  • Richard Morris
  • John Deanfield
  • Ann Donald
  • George Davey Smith
  • Mika Kivimaki
  • Meena Kumari
  • Liam Smeeth
  • Kay-Tee Khaw
  • Michael Nalls
  • James Meschia
  • Kai Sun
  • Rutai Hui
  • Ian Day
  • Aroon D Hingorani
  • Juan P Casas
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At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk.
Original languageEnglish
JournalInternational Journal of Epidemiology
Volume42
Issue number2
Pages (from-to)475-92
Number of pages18
ISSN0300-5771
DOIs
Publication statusPublished - Apr 2013

ID: 41875185