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Antipsychotics and associated risk of out-of-hospital cardiac arrest

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  • Peter Weeke
  • Aksel Jensen
  • Fredrik Folke
  • Gunnar Hilmar Gislason
  • Jonas Bjerring Olesen
  • Emil L Fosbøl
  • Mads Wissenberg
  • Freddy K Lippert
  • Erika Frischknecht Christensen
  • Søren Loumann Nielsen
  • Ellen Holm
  • Jørgen K Kanters
  • Henrik Enghusen Poulsen
  • Lars Køber
  • Christian Torp-Pedersen
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Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume96
Issue number4
Pages (from-to)490-497
ISSN0009-9236
DOIs
Publication statusPublished - 2014

ID: 44372023