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Rigshospitalet - a part of Copenhagen University Hospital
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Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

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  1. MAIT cell subtypes in multiple sclerosis

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  2. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

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  3. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

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  4. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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  1. Functional-structural assessment of the optic pathways in patients with optic neuritis

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  2. Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods

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  3. Sensitive Assessment of Acute Optic Neuritis by a New, Digital Flicker Test

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  4. Randomized trial of daily high-dose vitamin D3 in patients with RRMS receiving subcutaneous interferon β-1a

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  5. Author response: Nationwide prevalence and incidence study of neuromyelitis optica spectrum disorder in Denmark

    Research output: Contribution to journalComment/debateResearchpeer-review

  • Gunnar Houen
  • Julie Heiden
  • Nicole H Trier
  • Anette H Draborg
  • Michael E Benros
  • Rūta Zinkevičiūtė
  • Rasa Petraitytė-Burneikienė
  • Evaldas Ciplys
  • Rimantas Slibinskas
  • Jette L Frederiksen
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Antibody indices to Measles, Mumps, Varicella Zoster (MRZ) are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could be extended to increase diagnostic value. Samples from relapsing-remitting (RR) MS and optic neuritis (ON) patients were tested for reactivity to antigens from Epstein-Barr, Varicella Zoster, Measles, Mumps and Rubella (EMMRZ) viruses. Increased IgG levels in serum and cerebrospinal fluid (CSF) were found in RRMS patients, along with a significant correlation between serum and CSF. The sensitivity of the EMMRZ panel was increased approximately 40% compared to the MRZ panel, suggesting that the EMMRZ panel may be useful in MS and ON diagnostics.

Original languageEnglish
Article number577314
JournalJournal of Neuroimmunology
Volume346
Pages (from-to)577314
ISSN0165-5728
DOIs
Publication statusPublished - 2020

    Research areas

  • Epstein Barr virus, Multiple sclerosis, Neurotrophic virus, Optic neuritis, Virus antigens

ID: 60407158