Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection - significance of macrolide treatment

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Novel human in vitro vegetation simulation model for infective endocarditis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Systematic review on the current knowledge and use of Single-cell RNA Sequencing in Head and Neck Cancer

    Research output: Contribution to journalReviewResearchpeer-review

  3. The impact of mental models on the treatment and research of chronic infections due to biofilms

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Novel human in vitro vegetation simulation model for infective endocarditis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infection

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. APMIS pandemic editorial

    Research output: Contribution to journalEditorialResearchpeer-review

View graph of relations

Animal models of human diseases are invaluable and inevitable elements in identifying and testing novel treatments for serious diseases, including severe infections. Planning and conducting investigator-initiated human trials are generally accepted as being enormously challenging. In contrast, it is often underestimated how much planning, including background and modifying experiments, is needed to establish a relevant infectious disease animal model. However, representative animal infectious models, well designed to test generated hypotheses, are useful to improve our understanding of pathogenesis, virulence factors and host response and to identify novel treatment candidates and therapeutic strategies. Such results can subsequently proceed to clinical testing if suitable. The present review aims at presenting all the pulmonary Pseudomonas aeruginosa infectious models we have knowledge of and the detailed descriptions of established animal models in our laboratory focusing on macrolide therapy are presented.

Original languageEnglish
Article number13161
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Pages (from-to)1-19
Number of pages19
ISSN0903-4641
DOIs
Publication statusE-pub ahead of print - 12 Jun 2021

    Research areas

  • Animal model, biofilm, chronic lung infection, cystic fibrosis, immunology, macrolide

ID: 66308628