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Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

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@article{2c74d31e6e314cefbd7b5e86ff1fd82f,
title = "Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood",
abstract = "Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.",
author = "Bhattoa, {Harjit P} and Etienne Cavalier and Richard Eastell and Heijboer, {Annemieke C} and J{\o}rgensen, {Niklas R} and Konstantinos Makris and Ulmer, {Candice Z} and Kanis, {John A} and Cyrus Cooper and Silverman, {Stuart L} and Vasikaran, {Samuel D} and {IFCC-IOF Committee for Bone Metabolism}",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2021",
month = apr,
doi = "10.1016/j.cca.2020.12.023",
language = "English",
volume = "515",
pages = "16--20",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood

AU - Bhattoa, Harjit P

AU - Cavalier, Etienne

AU - Eastell, Richard

AU - Heijboer, Annemieke C

AU - Jørgensen, Niklas R

AU - Makris, Konstantinos

AU - Ulmer, Candice Z

AU - Kanis, John A

AU - Cooper, Cyrus

AU - Silverman, Stuart L

AU - Vasikaran, Samuel D

AU - IFCC-IOF Committee for Bone Metabolism

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.

AB - Procollagen type I N-propeptide (PINP) and the C-terminal telopeptide of type I collagen (β-CTX) in blood have been designated as reference bone turnover markers in osteoporosis by the International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The IFCC Committee on Bone Metabolism (C-BM) has examined current commercial assays and performed a multicentre study to examine the agreement between assays for PINP and β-CTX in serum and plasma. The results of these studies will inform our work towards the harmonization of PINP assays and the standardization of β-CTX assays in blood, with the development of common calibrators and reference measurement procedures in collaboration with the reagent manufacturing industry. Successful achievement of these goals will help develop universally acceptable practice guidelines for the management of osteoporosis with the inclusion of common reference intervals and treatment targets for PINP and β-CTX.

U2 - 10.1016/j.cca.2020.12.023

DO - 10.1016/j.cca.2020.12.023

M3 - Journal article

C2 - 33382995

VL - 515

SP - 16

EP - 20

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -

ID: 64127535