Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Alcohol Intake in Early Pregnancy and Risk of Attention-Deficit/Hyperactivity Disorder in Children Up to 19 Years of Age: A Cohort Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Alcohol intake in early pregnancy and spontaneous preterm birth: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Serum concentrations of mast cell tryptase are reduced in heavy drinkers

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Louise Katrine Kjaer Weile
  • Chunsen Wu
  • Hanne Kristine Hegaard
  • Ulrik Schiøler Kesmodel
  • Tine Brink Henriksen
  • Ellen Aagaard Nohr
View graph of relations

Background: Little is known about maternal alcohol intake in early pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in children beyond 5 years of age. We examined the association between alcohol binge drinking and weekly alcohol intake in early pregnancy and the risk of ADHD in children followed from birth to 19 years of age. Methods: We included 48,072 children born between 1998 and 2012, whose mothers participated in the Aarhus Birth Cohort. Maternal alcohol intake was obtained from a self-administered questionnaire completed in early pregnancy. ADHD diagnoses were retrieved from the Danish Psychiatric Central Research Register and the Danish National Patient Register. Crude hazard ratio and adjusted hazard ratio (aHR) of ADHD according to alcohol binge drinking or weekly intake of alcohol were calculated using the Cox regression. Results: Compared to children of women with no binge drinking episodes, we observed an aHR for ADHD of 0.91 (95% CI 0.76 to 1.08), 0.73 (95% CI 0.56 to 0.96), and 0.77 (95% CI 0.57 to 1.06) among children of women reporting 1, 2, and 3 or more binge drinking episodes, respectively. Among children of women drinking <1 drink per week, 1 drink per week, 2 drinks per week, and 3 or more drinks per week, we observed an aHR for ADHD of 0.87 (95% CI 0.74 to 1.03), 0.63 (95% CI 0.40 to 0.98), 1.30 (95% CI 0.89 to 1.92), and 0.78 (95% CI 0.38 to 1.59), respectively, when compared to children of women not drinking on a weekly basis. Conclusion: We found no evidence that binge drinking or low alcohol intake in early pregnancy was associated with the risk of ADHD in children.

Original languageEnglish
JournalAlcoholism: Clinical and Experimental Research
Volume44
Issue number1
Pages (from-to)168-177
Number of pages10
ISSN0145-6008
DOIs
Publication statusPublished - Jan 2020

    Research areas

  • ADHD Diagnosis, Binge Drinking, Low, Moderate Alcohol Consumption, Pregnancy, Prenatal Exposures

ID: 60978394