Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Aerobic fitness after JDM--a long-term follow-up study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Creation and implementation of a European registry for patients with McArdle disease and other muscle glycogenoses (EUROMAC registry)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bimagrumab vs Optimized Standard of Care for Treatment of Sarcopenia in Community-Dwelling Older Adults: A Randomized Clinical Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Vacuoles, Often Containing Glycogen, Are a Consistent Finding in Hypokalemic Periodic Paralysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Editorial: Remaining diagnostic issues and start of a treatment era for muscle diseases

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Objectives. It has previously been shown that patients with active JDM have decreased aerobic fitness; however, it is not known whether these patients regain their physical fitness after recovery. The objective of this study was to investigate the long-term outcome of aerobic fitness in patients with JDM. We hypothesized that fitness (VO(2max)) is reduced compared with healthy controls in the years after active JDM. Methods. A maximal exercise test was performed using a cycle ergometer. Results were compared with those of sex- and age-matched healthy controls. Results. A total of 36 patients with JDM in remission were included, 2-36 years after disease onset. Twelve patients (33%) had normal VO(2max) and 24 patients (67%) had decreased VO(2max). Mean VO(2max) was higher in the healthy controls vs patients (P <0.001, 95% CI -10.7, -4.4). A significant difference between patients with JDM and controls was observed for women (P <0.001), men (P = 0.04), children <18 years (P = 0.002) and adults > 18 years (P = 0.01). The decreased VO(2max) was independent of the duration of remission, but it was associated with the duration of active disease. By linear regression, it was revealed that for every year of active disease, VO(2max) was reduced by 0.85 ml/min/kg on average (P <0.001). Conclusion. This long-term follow-up study demonstrates that patients who have had JDM have persistently impaired fitness. This impairment is directly related to the duration of active disease.
Original languageEnglish
JournalRheumatology
Volume52
Issue number2
Pages (from-to)287-95
Number of pages9
ISSN1462-0324
DOIs
Publication statusPublished - 2013

ID: 36858227