Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Advanced dose calculation algorithms in lung cancer radiotherapy: Implications for SBRT and locally advanced disease in deep inspiration breath hold

Research output: Contribution to journalJournal articleResearchpeer-review

  1. [OA023] Multiparametric MRI measurements of renal perfusion and oxygenation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The impact of technology on the changing practice of lung SBRT

    Research output: Contribution to journalReviewResearchpeer-review

  3. Irregular breathing during 4DCT scanning of lung cancer patients: Is the midventilation approach robust?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Early Appearance of Coronavirus Disease 2019 Associated Pulmonary Infiltrates During Daily Radiotherapy Imaging for Lung Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients - initial observations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Pre-radiotherapy daily exercise training in non-small cell lung cancer: A feasibility study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: Evaluating performance of modern dose calculation algorithms in SBRT and locally advanced lung cancer radiotherapy in free breathing (FB) and deep inspiration breath hold (DIBH).

METHODS: For 17 patients with early stage and 17 with locally advanced lung cancer, a plan in FB and in DIBH were generated with Anisotropic Analytical Algorithm (AAA). Plans for early stage were 3D-conformal SBRT, 45 Gy in 3 fractions, prescribed to 95% isodose covering 95% of PTV and aiming for 140% dose centrally in the tumour. Locally advanced plans were volumetric modulated arc therapy, 66 Gy in 33 fractions, prescribed to mean PTV dose. Calculation grid size was 1 mm for SBRT and 2.5 mm for locally advanced plans. All plans were recalculated with AcurosXB with same MU as in AAA, for comparison on target coverage and dose to risk organs.

RESULTS: Lung volume increased in DIBH, resulting in decreased lung density (6% for early and 13% for locally-advanced group). In SBRT, AAA overestimated mean and near-minimum PTV dose (p-values < 0.01) compared to AcurosXB, with largest impact in DIBH (differences of up to 11 Gy). These clinically relevant differences may be a combination of small targets and large dose gradients within the PTV. In locally advanced group, AAA overestimated mean GTV, CTV and PTV doses by median less than 0.8 Gy and near-minimum doses by median 0.4-2.7 Gy. No clinically meaningful difference was observed for lung and heart dose metrics between the algorithms, for both FB and DIBH.

CONCLUSIONS: AAA overestimated target coverage compared to AcurosXB, especially in DIBH for SBRT.

Original languageEnglish
JournalPhysica Medica
Volume56
Pages (from-to)50-57
Number of pages8
ISSN1120-1797
DOIs
Publication statusPublished - Dec 2018

ID: 55866293