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Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain

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Artacho-Cordón, F, Ríos-Arrabal, S, León, J, Frederiksen, H, Sáenz, JM, Martín-Olmedo, P, Fernández, MF, Olea, N & Arrebola, JP 2019, 'Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain' Environment International, vol. 133, no. Pt A, 105118, pp. 105118. https://doi.org/10.1016/j.envint.2019.105118

APA

Artacho-Cordón, F., Ríos-Arrabal, S., León, J., Frederiksen, H., Sáenz, J. M., Martín-Olmedo, P., ... Arrebola, J. P. (2019). Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain. Environment International, 133(Pt A), 105118. [105118]. https://doi.org/10.1016/j.envint.2019.105118

CBE

Artacho-Cordón F, Ríos-Arrabal S, León J, Frederiksen H, Sáenz JM, Martín-Olmedo P, Fernández MF, Olea N, Arrebola JP. 2019. Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain. Environment International. 133(Pt A):105118. https://doi.org/10.1016/j.envint.2019.105118

MLA

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Author

Artacho-Cordón, F ; Ríos-Arrabal, S ; León, J ; Frederiksen, H ; Sáenz, J M ; Martín-Olmedo, P ; Fernández, M F ; Olea, N ; Arrebola, J P. / Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain. In: Environment International. 2019 ; Vol. 133, No. Pt A. pp. 105118.

Bibtex

@article{d6dddc8e541649cf9ab9b603713042d6,
title = "Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain",
abstract = "The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79]. Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.",
author = "F Artacho-Cord{\'o}n and S R{\'i}os-Arrabal and J Le{\'o}n and H Frederiksen and S{\'a}enz, {J M} and P Mart{\'i}n-Olmedo and Fern{\'a}ndez, {M F} and N Olea and Arrebola, {J P}",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2019",
month = "12",
doi = "10.1016/j.envint.2019.105118",
language = "English",
volume = "133",
pages = "105118",
journal = "Environmental International",
issn = "0160-4120",
publisher = "Pergamon",
number = "Pt A",

}

RIS

TY - JOUR

T1 - Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain

AU - Artacho-Cordón, F

AU - Ríos-Arrabal, S

AU - León, J

AU - Frederiksen, H

AU - Sáenz, J M

AU - Martín-Olmedo, P

AU - Fernández, M F

AU - Olea, N

AU - Arrebola, J P

N1 - Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79]. Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.

AB - The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative microenvironment in adipose tissue. This study was conducted in a subsample (n = 144) of the GraMo cohort (Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted for potential confounders. Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx) activity [exp(β) = 1.20, p = 0.060] and decreased levels of reduced glutathione (GSH) [exp(β) = 0.55, p = 0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione reductase (GRd) activity [exp(β) = 0.83, exp(β) = 0.72, respectively], and BPA was borderline associated to increased levels of oxidized glutathione (GSSG) [exp(β) = 1.73, p-value = 0.062]. MeP was inversely associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79]. Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.

UR - http://www.scopus.com/inward/record.url?scp=85072997836&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2019.105118

DO - 10.1016/j.envint.2019.105118

M3 - Journal article

VL - 133

SP - 105118

JO - Environmental International

JF - Environmental International

SN - 0160-4120

IS - Pt A

M1 - 105118

ER -

ID: 58289635