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Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort

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Harvard

Sepriano, A, Ramiro, S, FitzGerald, O, Østergaard, M, Homik, J, van der Heijde, D, Elkayam, O, Thorne, C, Larché, MJ, Ferraccioli, G, Backhaus, M, Burmester, GR, Boire, G, Combe, B, Saraux, A, Dougados, M, Rossini, M, Govoni, M, Sinigaglia, L, Cantagrel, A, Barnabe, C, Bingham, CO, Tak, PP, van Schaardenburg, D, Hammer, HB, Paschke, J, Dadashova, R, Hutchings, E, Landewé, R & Maksymowych, WP 2020, 'Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort' Journal of Rheumatology, vol. 47, no. 6, pp. 809-819. https://doi.org/10.3899/jrheum.190303

APA

CBE

Sepriano A, Ramiro S, FitzGerald O, Østergaard M, Homik J, van der Heijde D, Elkayam O, Thorne C, Larché MJ, Ferraccioli G, Backhaus M, Burmester GR, Boire G, Combe B, Saraux A, Dougados M, Rossini M, Govoni M, Sinigaglia L, Cantagrel A, Barnabe C, Bingham CO, Tak PP, van Schaardenburg D, Hammer HB, Paschke J, Dadashova R, Hutchings E, Landewé R, Maksymowych WP. 2020. Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort. Journal of Rheumatology. 47(6):809-819. https://doi.org/10.3899/jrheum.190303

MLA

Vancouver

Author

Sepriano, Alexandre ; Ramiro, Sofia ; FitzGerald, Oliver ; Østergaard, Mikkel ; Homik, Joanne ; van der Heijde, Désirée ; Elkayam, Ori ; Thorne, Carter ; Larché, Maggie J ; Ferraccioli, Gianfranco ; Backhaus, Marina ; Burmester, Gerd R ; Boire, Gilles ; Combe, Bernard ; Saraux, Alain ; Dougados, Maxime ; Rossini, Maurizio ; Govoni, Marcello ; Sinigaglia, Luigi ; Cantagrel, Alain ; Barnabe, Cheryl ; Bingham, Clifton O ; Tak, Paul P ; van Schaardenburg, Dirkjan ; Hammer, Hilde Berner ; Paschke, Joel ; Dadashova, Rana ; Hutchings, Edna ; Landewé, Robert ; Maksymowych, Walter P. / Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors : Data from the International RA BIODAM Cohort. In: Journal of Rheumatology. 2020 ; Vol. 47, No. 6. pp. 809-819.

Bibtex

@article{9c3f3de2ee6f4e089c906e897cdab78b,
title = "Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors: Data from the International RA BIODAM Cohort",
abstract = "OBJECTIVE: Compelling evidence supports a treat-to-target (T2T) strategy for optimal outcomes in rheumatoid arthritis (RA). There is limited knowledge regarding the factors that impede implementation of T2T, particularly in a setting where adherence to T2T is protocol-specified. We aimed to assess clinical factors that associate with failure to adhere to T2T.METHODS: Patients with RA from 10 countries who were starting or changing conventional synthetic disease-modifying antirheumatic drugs and/or starting tumor necrosis factor inhibitors were followed for 2 years. Participating physicians were required per protocol to adhere to the T2T strategy. Factors influencing adherence to T2T low disease activity (T2T-LDA; 44-joint count Disease Activity Score ≤ 2.4) were analyzed in 2 types of binomial generalized estimating equations models: (1) including only baseline features (baseline model); and (2) modeling variables that inherently vary over time as such (longitudinal model).RESULTS: A total of 571 patients were recruited and 439 (76.9{\%}) completed 2-year followup. Failure of adherence to T2T-LDA was noted in 1765 visits (40.5{\%}). In the baseline multivariable model, a high number of comorbidities (OR 1.10, 95{\%} CI 1.02-1.19), smoking (OR 1.32, 95{\%} CI 1.08-1.63) and high number of tender joints (OR 1.03, 95{\%} CI 1.02-1.04) were independently associated with failure to implement T2T, while anticitrullinated protein antibody/rheumatoid factor positivity (OR 0.63, 95{\%} CI 0.50-0.80) was a significant facilitator of T2T. Results were similar in the longitudinal model.CONCLUSION: Lack of adherence to T2T in the RA BIODAM cohort was evident in a substantial proportion despite being a protocol requirement, and this could be predicted by clinical features. [Rheumatoid Arthritis (RA) BIODAM cohort; ClinicalTrials.gov: NCT01476956].",
author = "Alexandre Sepriano and Sofia Ramiro and Oliver FitzGerald and Mikkel {\O}stergaard and Joanne Homik and {van der Heijde}, D{\'e}sir{\'e}e and Ori Elkayam and Carter Thorne and Larch{\'e}, {Maggie J} and Gianfranco Ferraccioli and Marina Backhaus and Burmester, {Gerd R} and Gilles Boire and Bernard Combe and Alain Saraux and Maxime Dougados and Maurizio Rossini and Marcello Govoni and Luigi Sinigaglia and Alain Cantagrel and Cheryl Barnabe and Bingham, {Clifton O} and Tak, {Paul P} and {van Schaardenburg}, Dirkjan and Hammer, {Hilde Berner} and Joel Paschke and Rana Dadashova and Edna Hutchings and Robert Landew{\'e} and Maksymowych, {Walter P}",
year = "2020",
month = "6",
day = "1",
doi = "10.3899/jrheum.190303",
language = "English",
volume = "47",
pages = "809--819",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Adherence to Treat-to-Target Management in Rheumatoid Arthritis and Associated Factors

T2 - Data from the International RA BIODAM Cohort

AU - Sepriano, Alexandre

AU - Ramiro, Sofia

AU - FitzGerald, Oliver

AU - Østergaard, Mikkel

AU - Homik, Joanne

AU - van der Heijde, Désirée

AU - Elkayam, Ori

AU - Thorne, Carter

AU - Larché, Maggie J

AU - Ferraccioli, Gianfranco

AU - Backhaus, Marina

AU - Burmester, Gerd R

AU - Boire, Gilles

AU - Combe, Bernard

AU - Saraux, Alain

AU - Dougados, Maxime

AU - Rossini, Maurizio

AU - Govoni, Marcello

AU - Sinigaglia, Luigi

AU - Cantagrel, Alain

AU - Barnabe, Cheryl

AU - Bingham, Clifton O

AU - Tak, Paul P

AU - van Schaardenburg, Dirkjan

AU - Hammer, Hilde Berner

AU - Paschke, Joel

AU - Dadashova, Rana

AU - Hutchings, Edna

AU - Landewé, Robert

AU - Maksymowych, Walter P

PY - 2020/6/1

Y1 - 2020/6/1

N2 - OBJECTIVE: Compelling evidence supports a treat-to-target (T2T) strategy for optimal outcomes in rheumatoid arthritis (RA). There is limited knowledge regarding the factors that impede implementation of T2T, particularly in a setting where adherence to T2T is protocol-specified. We aimed to assess clinical factors that associate with failure to adhere to T2T.METHODS: Patients with RA from 10 countries who were starting or changing conventional synthetic disease-modifying antirheumatic drugs and/or starting tumor necrosis factor inhibitors were followed for 2 years. Participating physicians were required per protocol to adhere to the T2T strategy. Factors influencing adherence to T2T low disease activity (T2T-LDA; 44-joint count Disease Activity Score ≤ 2.4) were analyzed in 2 types of binomial generalized estimating equations models: (1) including only baseline features (baseline model); and (2) modeling variables that inherently vary over time as such (longitudinal model).RESULTS: A total of 571 patients were recruited and 439 (76.9%) completed 2-year followup. Failure of adherence to T2T-LDA was noted in 1765 visits (40.5%). In the baseline multivariable model, a high number of comorbidities (OR 1.10, 95% CI 1.02-1.19), smoking (OR 1.32, 95% CI 1.08-1.63) and high number of tender joints (OR 1.03, 95% CI 1.02-1.04) were independently associated with failure to implement T2T, while anticitrullinated protein antibody/rheumatoid factor positivity (OR 0.63, 95% CI 0.50-0.80) was a significant facilitator of T2T. Results were similar in the longitudinal model.CONCLUSION: Lack of adherence to T2T in the RA BIODAM cohort was evident in a substantial proportion despite being a protocol requirement, and this could be predicted by clinical features. [Rheumatoid Arthritis (RA) BIODAM cohort; ClinicalTrials.gov: NCT01476956].

AB - OBJECTIVE: Compelling evidence supports a treat-to-target (T2T) strategy for optimal outcomes in rheumatoid arthritis (RA). There is limited knowledge regarding the factors that impede implementation of T2T, particularly in a setting where adherence to T2T is protocol-specified. We aimed to assess clinical factors that associate with failure to adhere to T2T.METHODS: Patients with RA from 10 countries who were starting or changing conventional synthetic disease-modifying antirheumatic drugs and/or starting tumor necrosis factor inhibitors were followed for 2 years. Participating physicians were required per protocol to adhere to the T2T strategy. Factors influencing adherence to T2T low disease activity (T2T-LDA; 44-joint count Disease Activity Score ≤ 2.4) were analyzed in 2 types of binomial generalized estimating equations models: (1) including only baseline features (baseline model); and (2) modeling variables that inherently vary over time as such (longitudinal model).RESULTS: A total of 571 patients were recruited and 439 (76.9%) completed 2-year followup. Failure of adherence to T2T-LDA was noted in 1765 visits (40.5%). In the baseline multivariable model, a high number of comorbidities (OR 1.10, 95% CI 1.02-1.19), smoking (OR 1.32, 95% CI 1.08-1.63) and high number of tender joints (OR 1.03, 95% CI 1.02-1.04) were independently associated with failure to implement T2T, while anticitrullinated protein antibody/rheumatoid factor positivity (OR 0.63, 95% CI 0.50-0.80) was a significant facilitator of T2T. Results were similar in the longitudinal model.CONCLUSION: Lack of adherence to T2T in the RA BIODAM cohort was evident in a substantial proportion despite being a protocol requirement, and this could be predicted by clinical features. [Rheumatoid Arthritis (RA) BIODAM cohort; ClinicalTrials.gov: NCT01476956].

U2 - 10.3899/jrheum.190303

DO - 10.3899/jrheum.190303

M3 - Journal article

VL - 47

SP - 809

EP - 819

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 6

ER -

ID: 58908459