Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital

ADHD medication and the inverted U-shaped curve: A pharmacological study in female mice performing the rodent Continuous Performance Test (rCPT)

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ectopic eruption of the second premolar: an analysis of four different treatment approaches

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Autotransplantation of Teeth to the Anterior Region

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

View graph of relations

BACKGROUND: The rodent Continuous Performance Test (rCPT) is an analogue of human CPTs where mice have to discriminate between target and non-target stimuli. The rCPT offers a readout of attentional performance and impulsive behaviour. This study aimed to determine if female C57BL/6 J mice could be trained in the rCPT since previously published rCPT studies have only used male mice and to study whether the effects of methylphenidate (MPH), atomoxetine (ATX), and dexamphetamine (AMPH) on attention and impulsivity depend on baseline (reference) levels of performance.

METHODS: 48 female mice underwent rCPT training. Effects of MPH (1, 2, and 3 mg/kg), ATX (1, 3, and 5 mg/kg) and AMPH (0.3, 0.6, and 1 mg/kg) were assessed in a variable stimulus duration probe. Drugs were administered intraperitoneally and sequentially tested following a Latin-square design. Data were analysed using a repeated measurements mixed effect model and reference-dependent effects were studied.

RESULTS: ATX and AMPH improved performance as seen by increases in discriminability. These improvements were a result of a decreased false-alarm rate. AMPH showed a reference-dependent effect, improving the task performance of low-performing mice and decreasing the performance of high-performing mice. MPH also showed this reference-dependent effects, albeit to a lesser extent. ATX and AMPH decreased premature responses and increased response criterion, but no reference-dependent effects were observed for these parameters.

CONCLUSION: This study presents a novel method to analyse baseline-dependent effects. It shows that the rCPT can be successfully used in pharmacological studies in female mice and demonstrates that the effect of ADHD medication is in line with the inverted U-shape theory of performance-arousal relationship.

Original languageEnglish
JournalProgress in neuro-psychopharmacology & biological psychiatry
Pages (from-to)109823
Publication statusPublished - 20 Apr 2020

    Research areas

  • ADHD medication, Attention, Impulsivity, Inverted U-shaped curve, Rodent continuous performance test

ID: 59291001