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Acute social defeat does not alter cerebral 5-HT2A receptor binding in male Wistar rats

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  1. Similar serotonin-2A receptor binding in rats with different coping styles or levels of aggression

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  3. Direct comparison of [(18) F]MH.MZ and [(18) F]altanserin for 5-HT(2A) receptor imaging with PET

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  2. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

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  3. Plasma psilocin critically determines behavioral and neurobiological effects of psilocybin

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  4. Imaging of the Serotonin System: Radiotracers and Applications in Memory Disorders

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  5. Metaboliske, endokrine og andre systemiske sygdomme

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

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It has been hypothesized that effects of uncontrollable stress on serotonin receptor expression contribute to the etiology of stress-related disorders like depression. While the serotonin-2A receptors (5-HT2A R) are thought to be important in this context, only few studies examined effects of stress on this receptor subtype. In this study, we therefore assessed acute and long-term changes in 5HT2A R binding after social defeat stress in rats. Male Wistar rats were subjected to social defeat by placing them in the home cage of an aggressive, dominant Long Evans rat. Acute social defeat suppressed growth, but did not affect anxiety-like behavior in an open field test. A positron emission tomography scan with the 5-HT2A R tracer [11C]MDL 100907 1 day and 3 weeks after defeat did not show significant changes in receptor binding. To verify these results, [3H]MDL 100907 binding assays were performed in homogenates of prefrontal cortex and hippocampus, which also did not indicate any changes in Bmax or Kd . These findings do not support the hypothesis that changes in 5-HT2A R function are a vital mechanism through which uncontrollable stress contributes to stress-related pathologies such as depression. It remains to be determined whether effects of stress on 5HT2A R binding depend on the nature of the stressor or on the characteristics of the rat strain.

Original languageEnglish
JournalSynapse (New York, N.Y.)
Volume68
Issue number9
Pages (from-to)379-86
Number of pages8
ISSN0887-4476
DOIs
Publication statusPublished - Sep 2014

ID: 44558333