Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Acinar cystic transformation of the pancreas: Report of a case and a review of the literature

Research output: Contribution to journalJournal articleResearchpeer-review

  1. ERCC1 expression in advanced colorectal cancer and matched liver metastases

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Atypical lymphocytes in bronchoalveolar lavage fluid from patients with COVID-19 ARDS

    Research output: Contribution to journalLetterResearchpeer-review

  3. Establishment of digital cutoff values for intraepithelial lymphocytes in biopsies from colonic mucosa with lymphocytic colitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Limited diagnostic utility of Chromogranin A measurements in workup of neuroendocrine tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prognostic impact of Charlson's Age-Comorbidity Index and other risk factors in patients with pancreatic cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A rare missense variant in APC interrupts splicing and causes AFAP in two Danish families

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Acinar cystic transformation (ACT) is a rare cystic lesion of the pancreas lately reclassified as a non-neoplastic entity. This is a presentation of a case of ACT and a review of the literature. A systematic PubMed search was conducted, yielding a result of 24 publications. Including our case report, 75 cases of ACT have been reported in the literature. The patients are mainly females with initial symptoms of abdominal pain. The cysts are primarily located in the head of the pancreas and are often multilocular on cross section and have a mean size of 53.2 mm. Microscopically, the cysts are lined by an acinar epithelium with abortive acinar formations. The cells are immunohistochemically positive in stains for trypsin, chymotrypsin and CK7. The Ki67-index is low; 1-2 %. No genetic alterations indicative of a neoplastic pathogenesis have been found. The mean follow up time is 37.4 months and no malignant transformation has been observed. A preoperative diagnosis is difficult to establish, but microbiopsies seem a promising tool. The indication for surgical intervention should be founded on the symptoms of the patients since no malignant transformation has ever been reported.

Original languageEnglish
JournalPathology, research and practice
Pages (from-to)152928
ISSN0344-0338
DOIs
Publication statusPublished - Jun 2020

ID: 60013884