Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

Academic performance in adolescents born to mothers with gestational diabetes - a national Danish cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Lipoprotein(a) levels at birth and in early childhood: The COMPARE Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Entero-pancreatic hormone secretion, gastric emptying, and glucose absorption after frequently sampled meal tests

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Vitamin D supplementation improves fasting insulin levels and HDL cholesterol in infertile men

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  5. Migration, gestational diabetes and adverse pregnancy outcomes: a nationwide study of singleton deliveries in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. GAD65 autoantibodies and glucose tolerance in offspring born to women with and without type 1 diabetes (The EPICOM study)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Børn født efter assisteret befrugtning

    Research output: Contribution to journalReviewResearchpeer-review

  3. Infertilitet er en gammel sygdom med nye behandlingsmuligheder

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Migration, gestational diabetes and adverse pregnancy outcomes: a nationwide study of singleton deliveries in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

CONTEXT: The prevalence of gestational diabetes mellitus (GDM) is increasing, and intrauterine hyperglycemia is suspected to affect offspring cognitive function.

OBJECTIVE: We assessed academic performance by grade point average (GPA) in children aged 15 to 16 years at compulsory school graduation, comparing offspring exposed to GDM (O-GDM) with offspring from the background population (O-BP).

METHODS: This register-based, cohort study comprised all singletons born in Denmark between 1994 and 2001 (O-GDM: n = 4286; O-BP: n = 501 045). Standardized and internationally comparable GPAs were compared in univariate and multivariable linear models. Main outcome measures included the adjusted mean difference in GPA. We also analyzed the probability of having a high GPA, a GPA below passing, and no GPA registered.

RESULTS: O-GDM had a GPA of 6.29 (SD 2.52), whereas O-BP had a GPA of 6.78 (SD 2.50). The adjusted mean difference was -0.36 (95% CI, -0.44 to -0.29), corresponding to a Cohen's D of 0.14. O-GDM had a lower probability of obtaining a high GPA (adjusted odds ratio [aOR] 0.68; 95% CI, 0.59 to 0.79), while their risk of obtaining a GPA below passing was similar to O-BP (aOR 1.20; 95% CI, 0.96 to 1.50). O-GDM had a higher risk of not having a GPA registered (aOR 1.38; 95% CI, 1.24 to 1.53).

CONCLUSION: Academic performance in O-GDM was marginally lower than in O-BP. However, this difference is unlikely to be of clinical importance.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume106
Issue number11
Pages (from-to)e4554-e4564
ISSN0021-972X
DOIs
Publication statusPublished - 21 Oct 2021

ID: 66575773