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Abnormal routine blood tests as predictors of mortality in acutely admitted patients

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  • Rasmus Roenhoej Rønhøj
  • Rasmus B Hasselbalch
  • Martin Schultz
  • Mia Pries-Heje
  • Louis L Plesner
  • Lisbet Ravn
  • Morten Lind
  • Birgitte N Jensen
  • Thomas Hoei-Hansen Høi-Hansen
  • Nicholas Carlson
  • Christian Torp-Pedersen
  • Lars S Rasmussen
  • Line J H Rasmussen
  • Jesper Eugen-Olsen
  • Lars Koeber Køber
  • Kasper Iversen
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BACKGROUND: This study aimed to improve early risk stratification in the emergency department by creating a simple blood test score based on routine biomarkers and assess its predictive ability for 30-day mortality of acutely admitted patients.

METHODS: This was a secondary analysis of data from the TRIAGE II study. It included unselected acutely admitted medical and surgical patients, who had albumin, C-reactive protein, creatinine, haemoglobin, leukocytes, potassium, sodium and thrombocytes levels analysed upon admission. Patients were classified according to the number of biomarker results outside the reference range into four risk groups termed "very low", "low", "intermediate", and "high" with 0-1, 2-3, 4-5 and 6-8 abnormal biomarker results, respectively. Logistic regression was used to calculate odds ratios for 30-day mortality and receiver operating characteristic was used to test the discriminative value. The primary analysis was done in patients triaged with ADAPT (Adaptive Process Triage). Subsequently, we analysed two other cohorts of acutely admitted patients.

RESULTS: The TRIAGE II cohort included 17,058 eligible patients, 30-day mortality was 5.2%. The primary analysis included 7,782 patients. Logistic regression adjusted for age and sex showed an OR of 24.1 (95% CI 14.9-41.0) between the very low- and the high-risk group. The area under the curve (AUC) was 0.79 (95% CI 0.76-0.81) for the blood test score in predicting 30-day mortality. The subsequent analyses confirmed the results.

CONCLUSIONS: A blood test score based on number of routine biomarkers with an abnormal result was a predictor of 30-day mortality in acutely admitted patients.

Original languageEnglish
JournalClinical Biochemistry
Volume77
Pages (from-to)14-19
Number of pages6
ISSN0009-9120
DOIs
Publication statusPublished - Mar 2020

Bibliographical note

Copyright © 2019 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

    Research areas

  • Emergency department, Mortality, Risk stratification, Routine biomarkers, Triage

ID: 58645894