Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Low adherence to the guideline for the acute treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Biochemical abnormalities among patients referred for celiac disease antibody blood testing in a primary health care setting

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Reduced levels of pulmonary surfactant in COVID-19 ARDS

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Diagnostic radiological examinations and risk of intracranial tumours in adults-findings from the Interphone Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pooled analysis of recent studies of magnetic fields and childhood leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Postoperative epilepsy and survival in glioma patients: a nationwide population-based cohort study from 2009 to 2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Pregnancy outcomes in women with neurofibromatosis 1: a Danish population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Maral Adel Fahmideh
  • Catharina Lavebratt
  • Giorgio Tettamanti
  • Joachim Schüz
  • Martin Röösli
  • Kristina Kjaerheim
  • Michael A Grotzer
  • Christoffer Johansen
  • Claudia E Kuehni
  • Birgitta Lannering
  • Lisbeth S Schmidt
  • Hatef Darabi
  • Maria Feychting
View graph of relations

Genetic risk score (GRS) is used to demonstrate the genetic variants contributing to the polygenic architecture of complex diseases. By using a GRS, we have investigated the additive impact of the known adult glioma susceptibility loci on the pediatric brain tumor (PBT) risk and assessed the proportion of PBT heritability attributable to these susceptibility loci. A GRS was generated for PBTs based on the alleles and associated effect sizes derived from a previously published genome-wide association study on adult glioma. The GRS was calculated in CEFALO, a population-based case-control study of brain tumors in children and adolescents including saliva DNA of 245 cases and 489 controls. The unconditional logistic regression model was used to investigate the association between standardized GRS and risk of PBTs. To measure the variance explained by the effect of GRS, Nagelkerke pseudo-R2 was calculated. The GRS for adult brain tumors was associated with an increased risk of PBTs (OR 1.25 [95% CI 1.06-1.49], p = 0.009) and 0.3% of the variance in PBTs could be explained by the effect of GRS on the liability scale. This study provides evidence that heritable risks of PBTs are in-part attributable to some common genetic variants associated with adult glioma.

Original languageEnglish
Article number18142
JournalScientific Reports
Volume9
ISSN2045-2322
DOIs
Publication statusPublished - 2 Dec 2019

ID: 59234725