Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma-a case report

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Fluorescein-guided resection of cerebral metastases is associated with greater tumor resection

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Right temporal lobe epilepsy surgery activates suppressed post-traumatic stress disorder 31 years after a robbery

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Proposal of a new grading system for meningioma resection: the Copenhagen Protocol

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Burr hole craniostomy versus minicraniotomy in chronic subdural hematoma: a comparative cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Deep learning for Dixon MRI-based attenuation correction in PET/MRI of head and neck cancer patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sex Differences and Caffeine Impact in Adenosine-Induced Hyperemia

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.

Original languageEnglish
JournalActa Neurochirurgica
Volume164
Issue number1
Pages (from-to)267-271
Number of pages5
ISSN0001-6268
DOIs
Publication statusPublished - Jan 2022

Bibliographical note

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

    Research areas

  • Brain surgery, FG001, Fluorescense, Meningiomas, Radicality, uPar

ID: 68903815