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Rigshospitalet - a part of Copenhagen University Hospital
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A Major Mycobacterium tuberculosis outbreak caused by one specific genotype in a low-incidence country: Exploring gene profile virulence explanations

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  1. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis

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  2. A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders

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  3. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

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  4. A Weighted Genetic Risk Score of Adult Glioma Susceptibility Loci Associated with Pediatric Brain Tumor Risk

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  5. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

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  1. Tuberculosis among Patients Undergoing Solid Organ Transplantation or Dialysis in a Low-Endemic Country, 2004-2017

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  2. Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report

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  3. Vi skal blive bedre til at teste for latent tuberkulose i Danmark

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  4. Extrapulmonary Tuberculosis in Denmark From 2009 to 2014; Characteristics and Predictors for Treatment Outcome

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  5. A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis Drugs

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Denmark, a tuberculosis low burden country, still experiences significant active Mycobacterium tuberculosis (Mtb) transmission, especially with one specific genotype named Cluster 2/1112-15 (C2), the most prevalent lineage in Scandinavia. In addition to environmental factors, antibiotic resistance, and human genetics, there is increasing evidence that Mtb strain variation plays a role for the outcome of infection and disease. In this study, we explore the reasons for the success of the C2 genotype by analysing strain specific polymorphisms identified through whole genome sequencing of all C2 isolates identified in Denmark between 1992 and 2014 (n = 952), and the demographic distribution of C2. Of 234 non-synonymous (NS) monomorphic SNPs found in C2 in comparison with Mtb reference strain H37Rv, 23 were in genes previously reported to be involved in Mtb virulence. Of these 23 SNPs, three were specific for C2 including a NS mutation in a gene associated with hyper-virulence. We show that the genotype is readily transmitted to different ethnicities and is also found outside Denmark. Our data suggest that strain specific virulence factor variations are important for the success of the C2 genotype. These factors, likely in combination with poor TB control, seem to be the main drivers of C2 success.

Original languageEnglish
JournalScientific Reports
Volume8
Issue number1
Pages (from-to)11869
ISSN2045-2322
DOIs
Publication statusPublished - 8 Aug 2018

ID: 56393648