Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

A high fraction of inspired oxygen may increase mortality in intubated trauma patients - A retrospective cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hemorrhage and saline resuscitation are associated with epigenetic and proteomic reprogramming in the rat lung

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Contemporary management of penetrating renal trauma - A national analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Survival and health related quality of life after severe trauma - a 15 years follow up study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The Role of a Physician-Staffed Helicopter in Emergency Care of Patients on Isolated Danish Islands

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Ketamine versus propofol for rapid sequence induction in trauma patients: a retrospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Mechanical ventilation of trauma patients is common, and many will require a higher than normal fraction of inspired oxygen (FiO2) to avoid hypoxaemia. The primary objective of this study was to assess the association between FiO2 and all-cause, one-year mortality in intubated trauma patients.

METHODS: Adult trauma patients intubated in the initial phase post-trauma between 2015 and 2017 were retrospectively identified. Information on FiO2 during the first 24 hours of hospitalisation and mortality was registered. For each patient the number of hours of the first 24 hours exposed to an FiO2 ≥ 80%, ≥ 60%, and ≥ 40%, respectively, were determined and categorised into exposure durations. The associations of these FiO2 exposures with mortality were evaluated using Cox regression adjusting for age, sex, body mass index (BMI), Injury Severity Score (ISS), prehospital Glasgow Coma Scale (GCS) score, and presence of thoracic injuries.

RESULTS: We included 218 intubated trauma patients. The median prehospital GCS score was 6 and the median ISS was 25. One-year mortality was significantly increased when patients had received an FiO2 above 80% for 3-4 hours compared to <2 hours (hazard ratio (95% CI) 2.7 (1.3-6.0), p= 0.011). When an FiO2 above 80% had been administered for more than 4 hours, there was a trend towards a higher mortality as well, but this was not statistically significant. There was a significant, time-dependent increase in mortality for patients who had received an FiO2 ≥ 60%. There was no significant relationship observed between mortality and the duration of FiO2 ≥ 40%.

CONCLUSION: A fraction of inspired oxygen above 60% for more than 2 hours during the first 24 hours of admission was associated with increased mortality in intubated trauma patients in a duration-dependent manner. However, given the limitations of this retrospective study, the findings need to be confirmed in a larger, randomized set-up.

Original languageEnglish
JournalInjury
ISSN0020-1383
DOIs
Publication statusE-pub ahead of print - 17 Sep 2021

Bibliographical note

Copyright © 2021. Published by Elsevier Ltd.

    Research areas

  • Airway, Hyperoxia, Mechanical Ventilation, Resuscitation, Trauma

ID: 68093987