A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients
Research output: Contribution to journal › Journal article › Research › peer-review
The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19 associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (DXM+ or DXM-) and 8 non-COVID-19 critically ill controls. CARDS (+DXM) was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis and FC-gamma receptor signalling. Most ISGs were upregulated in CARDS, particularly in CARDS (-DXM). In conclusion, DXM treatment was not associated with regulation of pro-inflammatory pathways in CARDS but with regulation of other local immune responses.
| Original language | English |
|---|---|
| Article number | jiac218 |
| Journal | The Journal of infectious diseases |
| Pages (from-to) | 1-13 |
| Number of pages | 13 |
| ISSN | 0022-1899 |
| DOIs | |
| Publication status | E-pub ahead of print - 27 May 2022 |
Bibliographical note
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America and HIV Medicine Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
- acute respiratory distress syndrome, bronchoalveolar lavage fluid, coronavirus disease 2019, inflammation, interferon stimulated genes, transcriptome profiling
Research areas
ID: 78452800