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Rigshospitalet - a part of Copenhagen University Hospital
E-pub ahead of print

A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

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The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19 associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (DXM+ or DXM-) and 8 non-COVID-19 critically ill controls. CARDS (+DXM) was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis and FC-gamma receptor signalling. Most ISGs were upregulated in CARDS, particularly in CARDS (-DXM). In conclusion, DXM treatment was not associated with regulation of pro-inflammatory pathways in CARDS but with regulation of other local immune responses.

Original languageEnglish
Article numberjiac218
JournalThe Journal of infectious diseases
Pages (from-to)1-13
Number of pages13
ISSN0022-1899
DOIs
Publication statusE-pub ahead of print - 27 May 2022

Bibliographical note

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America and HIV Medicine Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

    Research areas

  • acute respiratory distress syndrome, bronchoalveolar lavage fluid, coronavirus disease 2019, inflammation, interferon stimulated genes, transcriptome profiling

ID: 78452800