Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 PET and hyperpolarized [1-13C] pyruvate MRSI (hyperPET) in canine cancer patients: simultaneous imaging of angiogenesis and the Warburg effect

Research output: Contribution to journalJournal articleResearchpeer-review

  1. COVID-19 and the brain: impact on nuclear medicine in neurology

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pharmacokinetic analysis of [68Ga]Ga-DOTA-TOC PET in meningiomas for assessment of in vivo somatostatin receptor subtype 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High Sympathetic Activity in Raynaud's Disease

    Research output: Contribution to journalConference articleResearchpeer-review

  4. EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. In vivo imaging of cell proliferation in meningioma using 3'-deoxy-3'-[18F]fluorothymidine PET/MRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Non-invasive assessment of temporal changes in myocardial microvascular function in persons with type 2 diabetes and healthy controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Chronic Kidney Disease-Induced Vascular Calcification Impairs Bone Metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of apoA-I PEGylation on the Biological Fate of Biomimetic High-Density Lipoproteins

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: Cancer has a multitude of phenotypic expressions and identifying these are important for correct diagnosis and treatment selection. Clinical molecular imaging such as positron emission tomography can access several of these hallmarks of cancer non-invasively. Recently, hyperpolarized magnetic resonance spectroscopy with [1-13C] pyruvate has shown great potential to probe metabolic pathways. Here, we investigate simultaneous dual modality clinical molecular imaging of angiogenesis and deregulated energy metabolism in canine cancer patients.

METHODS: Canine cancer patients (n = 11) underwent simultaneous [68Ga]Ga-NODAGA-E[(cRGDyK)]2 (RGD) PET and hyperpolarized [1-13C]pyruvate-MRSI (hyperPET). Standardized uptake values and [1-13C]lactate to total 13C ratio were quantified and compared generally and voxel-wise.

RESULTS: Ten out of 11 patients showed clear tumor uptake of [68Ga]Ga-NODAGA-RGD at both 20 and 60 min after injection, with an average SUVmean of 1.36 ± 0.23 g/mL and 1.13 ± 0.21 g/mL, respectively. A similar pattern was seen for SUVmax values, which were 2.74 ± 0.41 g/mL and 2.37 ± 0.45 g/mL. The [1-13C]lactate generation followed patterns previously reported. We found no obvious pattern or consistent correlation between the two modalities. Voxel-wise tumor values of RGD uptake and lactate generation analysis revealed a tendency for each canine cancer patient to cluster in separated groups.

CONCLUSION: We demonstrated combined imaging of [68Ga]Ga-NODAGA-RGD-PET for angiogenesis and hyperpolarized [1-13C]pyruvate-MRSI for probing energy metabolism. The results suggest that [68Ga]Ga-NODAGA-RGD-PET and [1-13C]pyruvate-MRSI may provide complementary information, indicating that hyperPET imaging of angiogenesis and energy metabolism is able to aid in cancer phenotyping, leading to improved therapy planning.

Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume48
Issue number2
Pages (from-to)395-405
Number of pages11
ISSN1619-7070
DOIs
Publication statusPublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020, The Author(s).

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • Angiogenesis-PET, Cancer, Ga-RDG, Glycolysis, Hyperpolarized magnetic resonance spectroscopy imaging, Positron emission tomography, [1- C]pyruvate, hyperPET, [1-C-13]pyruvate, Ga-68-RDG

ID: 62406485