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Rigshospitalet - a part of Copenhagen University Hospital
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18F-FDG PET/CT-based early treatment response evaluation of nanoparticle-assisted photothermal cancer therapy

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  1. Novel functions of the luteinizing hormone/chorionic gonadotropin receptor in prostate cancer cells and patients

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  2. Hepatitis C prevalence in Denmark in 2016-An updated estimate using multiple national registers

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  3. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

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  4. Dyslipidemia at diagnosis of childhood acute lymphoblastic leukemia

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  1. Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis

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  2. Limited diagnostic utility of Chromogranin A measurements in workup of neuroendocrine tumors

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  3. Changes in cardiac microvascular function in persons with type 2 diabetes in relation to kidney function

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Within the field of nanoparticle-assisted photothermal cancer therapy, focus has mostly been on developing novel heat-generating nanoparticles with the right optical and dimensional properties. Comparison and evaluation of their performance in tumor-bearing animals are commonly assessed by changes in tumor volume; however, this is usually a late-occurring event. This study implements 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging to perform early evaluation of the treatment outcome of photothermal therapy. Silica-gold nanoshells (NS) are administered intravenously to nude mice bearing human neuroendocrine tumor xenografts and the tumors are irradiated by a near-infrared laser. The animals are positron emission tomography scanned with 2-deoxy-2-[F-18]fluoro-D-glucose one day before and one day after treatment. Using this setup, a significant decrease in tumor uptake of 2-deoxy-2-[F-18]fluoro-D-glucose is found already one day after therapy in the group receiving NS and laser treatment compared to control animals. At this time point no change in tumor volume can be detected. Moreover, the change in tumor uptake, is used to stratify the animals into responders and non-responders, where the responding group matched improved survival. Overall, these findings support the use of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging for preclinical and clinical evaluation and optimization of photothermal therapy.

Original languageEnglish
JournalP L o S One
Volume12
Issue number5
Pages (from-to)e0177997
ISSN1932-6203
DOIs
Publication statusPublished - May 2017

    Research areas

  • Animals, Cell Line, Tumor, Disease Models, Animal, Female, Fluorodeoxyglucose F18, Humans, Metal Nanoparticles, Mice, Mice, Nude, Neoplasms, Photochemotherapy, Positron Emission Tomography Computed Tomography, Treatment Outcome, Xenograft Model Antitumor Assays, Journal Article

ID: 52705699