Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
Published

18F-FDG PET/CT-based early treatment response evaluation of nanoparticle-assisted photothermal cancer therapy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dancing with atrial fibrillation - How arrhythmia affects everyday life of family members: A qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genetic markers of abdominal obesity and weight loss after gastric bypass surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Within the field of nanoparticle-assisted photothermal cancer therapy, focus has mostly been on developing novel heat-generating nanoparticles with the right optical and dimensional properties. Comparison and evaluation of their performance in tumor-bearing animals are commonly assessed by changes in tumor volume; however, this is usually a late-occurring event. This study implements 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging to perform early evaluation of the treatment outcome of photothermal therapy. Silica-gold nanoshells (NS) are administered intravenously to nude mice bearing human neuroendocrine tumor xenografts and the tumors are irradiated by a near-infrared laser. The animals are positron emission tomography scanned with 2-deoxy-2-[F-18]fluoro-D-glucose one day before and one day after treatment. Using this setup, a significant decrease in tumor uptake of 2-deoxy-2-[F-18]fluoro-D-glucose is found already one day after therapy in the group receiving NS and laser treatment compared to control animals. At this time point no change in tumor volume can be detected. Moreover, the change in tumor uptake, is used to stratify the animals into responders and non-responders, where the responding group matched improved survival. Overall, these findings support the use of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography imaging for preclinical and clinical evaluation and optimization of photothermal therapy.

Original languageEnglish
JournalP L o S One
Volume12
Issue number5
Pages (from-to)e0177997
ISSN1932-6203
DOIs
Publication statusPublished - May 2017

    Research areas

  • Animals, Cell Line, Tumor, Disease Models, Animal, Female, Fluorodeoxyglucose F18, Humans, Metal Nanoparticles, Mice, Mice, Nude, Neoplasms, Photochemotherapy, Positron Emission Tomography Computed Tomography, Treatment Outcome, Xenograft Model Antitumor Assays, Journal Article

ID: 52705699