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Rigshospitalet - a part of Copenhagen University Hospital

Exposure-outcome relationships in male urogenital malformations with special reference to endocrine disrupters

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Project funded by the European Union under the Quality of Life and Management of Living Resources Programme, Key Action 4: QLK4-CT-2001-00269
The study was based on a unique collection of biological material from a previous prospective study of 5800 women and their sons. Blood samples of the pregnant women, placenta specimens, cord blood and blood samples from the boys at 3 months of age, and breast milk samples have been collected. The infants from two European areas, with a low and a high incidence of genital abnormalities, respectively, have been examined and followed up. Their genitals have been examined with standardised techniques, including ultrasound of the testis, measurement of penile length, position of the testes and changes in testicular position during the follow-up. All abnormalities of the genitalia, including undescended testes and hypospadias have been diagnosed, and 6 reproductive hormones have been measured. Questionnaire information concerning environmental issues was obtained from the women during their pregnancies (occupation, reproductive history, medication, diet, alcohol and coffee consumption, use of cosmetics). 215 boys with urogenital abnormalities and 380 matched controls will be selected for analyses of placenta and breast milk for putative endocrine disrupters: dioxins, polychlorinated biphenyls, polybrominated diphenyl ethers, halogenated hydrocarbons, selected pesticides, phthalates, alkylphenols, and bisphenol A. Three collaborating laboratories will perform the chemical analyses. All chemical data together with information from questionnaires, reproductive hormone profiles, and clinical investigations was entered into a centralised database. Exposure - outcome relationships were invistigated especially in relation to the associations betweenexposure levels to the analysed chemicals or their combinations and the incidences of male urogenital disorders.

ID: 46416458