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Rigshospitalet - a part of Copenhagen University Hospital
  1. 2021
  2. E-pub ahead of print
  3. Published

    Immune Cell Profiling of Peripheral Blood as Signature for Response During Checkpoint Inhibition Across Cancer Types

    Araujo B de Lima, V., Hansen, M., Spanggaard, I., Rohrberg, K., Reker Hadrup, S., Lassen, U. & Svane, I. M., 25 Mar 2021, In: Frontiers in Oncology. 11, p. 558248 558248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2020
  5. Published

    Phase I/IIa, open-label, multicentre study to evaluate the optimal dosing and safety of ODM-203 in patients with advanced or metastatic solid tumours

    Bono, P., Massard, C., Peltola, K. J., Azaro, A., Italiano, A., Kristeleit, R. S., Curigliano, G., Lassen, U., Arkenau, H-T., Hakulinen, P., Garratt, C., Ikonen, T., Mustonen, M. V. J. & Rodon, J. A., Dec 2020, In: ESMO Open. 5, 6, p. e001081

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Phase 1 study of the immunotoxin LMB-100 in patients with mesothelioma and other solid tumors expressing mesothelin

    Hassan, R., Alewine, C., Mian, I., Spreafico, A., Siu, L. L., Gomez-Roca, C., Delord, J-P., Italiano, A., Lassen, U., Soria, J-C., Bahleda, R., Thomas, A., Steinberg, S. M., Peer, C. J., Figg, W. D., Niederfellner, G., Méresse Naegelen, V. & Pastan, I., 15 Nov 2020, In: Cancer. 126, 22, p. 4936-4947 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis

    Italiano, A., Nanda, S., Briggs, A., Garcia-Foncillas, J., Lassen, U., Vassal, G., Kummar, S., van Tilburg, C. M., Hong, D. S., Laetsch, T. W., Keating, K., Reeves, J. A., Fellous, M., Childs, B. H., Drilon, A. & Hyman, D. M., 4 Nov 2020, In: Cancers. 12, 11

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Dabrafenib plus trametinib in patients with BRAFV600E-mutated biliary tract cancer - Authors' reply

    Subbiah, V., Lassen, U., Gasal, E., Burgess, P. & Wainberg, Z. A., Nov 2020, In: Lancet Oncology. 21, 11, p. e516

    Research output: Contribution to journalComment/debateResearchpeer-review

  9. Published
  10. Published

    Dabrafenib plus trametinib in patients with BRAFV600E-mutated biliary tract cancer (ROAR): a phase 2, open-label, single-arm, multicentre basket trial

    Subbiah, V., Lassen, U., Élez, E., Italiano, A., Curigliano, G., Javle, M., de Braud, F., Prager, G. W., Greil, R., Stein, A., Fasolo, A., Schellens, J. H. M., Wen, P. Y., Viele, K., Boran, A. D., Gasal, E., Burgess, P., Ilankumaran, P. & Wainberg, Z. A., Sep 2020, In: The Lancet Oncology. 21, 9, p. 1234-1243 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Total burden of disease in cancer patients at diagnosis-a Danish nationwide study of multimorbidity and redeemed medication

    Loeppenthin, K., Dalton, S. O., Johansen, C., Andersen, E., Christensen, M. B., Pappot, H., Petersen, L. N., Thisted, L. B., Frølich, A., Mortensen, C. E., Lassen, U., Ørsted, J. & Bidstrup, P. E., Sep 2020, In: British Journal of Cancer. 123, 6, p. 1033-1040 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published
  13. Published

    Common phenotypic dynamics of tumor-infiltrating lymphocytes across different histologies upon checkpoint inhibition: impact on clinical outcome

    Araujo B de Lima, V., Borch, A., Hansen, M., Draghi, A., Spanggaard, I., Rohrberg, K., Reker Hadrup, S., Lassen, U. & Svane, I. M., Apr 2020, In: Cytotherapy. 22, 4, p. 204-213 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma

    Even, C., Lassen, U., Merchan, J., Le Tourneau, C., Soria, J-C., Ferte, C., Ricci, F., Diener, J. T., Yuen, E., Smith, C., Oakley, G. J., Benhadji, K. A. & Massard, C., Apr 2020, In: Investigational New Drugs. 38, 2, p. 402-409 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Tisotumab Vedotin in Previously Treated Recurrent or Metastatic Cervical Cancer

    Hong, D. S., Concin, N., Vergote, I., de Bono, J. S., Slomovitz, B. M., Drew, Y., Arkenau, H-T., Machiels, J-P., Spicer, J., Jones, R., Forster, M., Cornez, N., Gennigens, C., Johnson, M. L., Thistlethwaite, F. C., Rangwala, R. A., Ghatta, S., Windfeld, K., Harris, J. R., Lassen, U. N. & Coleman, R. L., 15 Mar 2020, In: Clinical Cancer Research. 26, 6, p. 1220-1228 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Testing NTRK testing: Wet-lab and in silico comparison of RNA-based targeted sequencing assays

    Pfarr, N., Kirchner, M., Lehmann, U., Leichsenring, J., Merkelbach-Bruse, S., Glade, J., Hummel, M., Stögbauer, F., Lehmann, A., Trautmann, M., Kumbrink, J., Jung, A., Dietmaier, W., Endris, V., Kazdal, D., Evert, M., Horst, D., Kreipe, H., Kirchner, T., Wardelmann, E., Lassen, U., Büttner, R., Weichert, W., Dietel, M., Schirmacher, P. & Stenzinger, A., Mar 2020, In: Genes, Chromosomes & Cancer. 59, 3, p. 178-188 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Entrectinib for ROS1 fusion-positive NSCLC and NTRK fusion-positive solid tumours

    Lassen, U., Feb 2020, In: Lancet Oncology. 21, 2, p. 193-194 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  18. 2019
  19. Published

    Criteria for site selection in industry-sponsored clinical trials: a survey among decision-makers in biopharmaceutical companies and clinical research organizations

    Dombernowsky, T., Haedersdal, M., Lassen, U. & Thomsen, S. F., 11 Dec 2019, In: Trials. 20, 1, 708.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    An open-label phase IB study to evaluate GSK3052230 in combination with paclitaxel and carboplatin, or docetaxel, in FGFR1-amplified non-small cell lung cancer

    Morgensztern, D., Karaseva, N., Felip, E., Delgado, I., Burdaeva, O., Dómine, M., Lara, P., Paik, P. K., Lassen, U., Orlov, S., Trigo, J., Shomova, M., Baker-Neblett, K., Vasquez, J., Wang, X., Yan, L., Mitrica, I., DeYoung, M. P. & Garrido, P., Oct 2019, In: Lung cancer. 136, p. 74-79 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24

    Mirza, M. R., Bergmann, T. K., Mau-Sørensen, M., Christensen, R. D., Åvall-Lundqvist, E., Birrer, M. J., Jørgensen, M., Roed, H., Malander, S., Nielsen, F., Lassen, U., Brøsen, K., Bjørge, L. & Mäenpää, J., Oct 2019, In: Cancer Chemotherapy and Pharmacology. 84, 4, p. 791-798 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Combining PARP inhibition with PD-1 inhibitors

    Lassen, U., Sep 2019, In: Lancet Oncology. 20, 9, p. 1196-1198 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein

    Bang-Christensen, S. R., Pedersen, R. S., Pereira, M. A., Clausen, T. M., Løppke, C., Sand, N. T., Ahrens, T. D., Jørgensen, A. M., Lim, Y. C., Goksøyr, L., Choudhary, S., Gustavsson, T., Dagil, R., Daugaard, M., Sander, A. F., Torp, M. H., Søgaard, M., Theander, T. G., Østrup, O., Lassen, U., Hamerlik, P., Salanti, A. & Agerbæk, M. Ø., 28 Aug 2019, In: Cells. 8, 9, p. E998

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. Published
  26. Published

    Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma

    Shraibman, B., Barnea, E., Kadosh, D. M., Haimovich, Y., Slobodin, G., Rosner, I., López-Larrea, C., Hilf, N., Kuttruff, S., Song, C., Britten, C., Castle, J., Kreiter, S., Frenzel, K., Tatagiba, M., Tabatabai, G., Dietrich, P-Y., Dutoit, V., Wick, W., Platten, M., Winkler, F., von Deimling, A., Kroep, J., Sahuquillo, J., Martinez-Ricarte, F., Rodon, J., Lassen, U., Ottensmeier, C., van der Burg, S. H., Thor Straten, P., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H-G., Sahin, U., Singh, H. & Admon, A., Jun 2019, 1 p.

    Research output: Other contributionResearch

  27. Published

    Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial

    de Bono, J. S., Concin, N., Hong, D. S., Thistlethwaite, F. C., Machiels, J-P., Arkenau, H-T., Plummer, R., Jones, R. H., Nielsen, D., Windfeld, K., Ghatta, S., Slomovitz, B. M., Spicer, J. F., Yachnin, J., Ang, J. E., Mau-Sørensen, P. M., Forster, M. D., Collins, D., Dean, E., Rangwala, R. A. & Lassen, U., Mar 2019, In: Lancet Oncology. 20, 3, p. 383-393 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Application of cell-free DNA for genomic tumor profiling: a feasibility study

    Ahlborn, L. B., Rohrberg, K. S., Gabrielaite, M., Tuxen, I. V., Yde, C. W., Spanggaard, I., Santoni-Rugiu, E., Nielsen, F. C., Lassen, U., Mau-Sorensen, M. & Østrup, O., 15 Feb 2019, In: Oncotarget. 10, 14, p. 1388-1398 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma

    Hilf, N., Kuttruff-Coqui, S., Frenzel, K., Bukur, V., Stevanović, S., Gouttefangeas, C., Platten, M., Tabatabai, G., Dutoit, V., van der Burg, S. H., Straten, P. T., Martinez-Ricarte, F., Ponsati, B., Okada, H., Lassen, U., Admon, A., Ottensmeier, C. H., Ulges, A., Kreiter, S., von Deimling, A., Skardelly, M., Migliorini, D., Kroep, J. R., Idorn, M., Rodon, J., Piro, J., Poulsen, H. S., Shraibman, B., McCann, K., Mendrzyk, R., Lower, M., Stieglbauer, M., Britten, C. M., Capper, D., Welters, M. J. P., Sahuquillo, J., Kiesel, K., Derhovanessian, E., Rusch, E., Bunse, L., Song, C., Heesch, S., Wagner, C., Kemmer-Bruck, A., Ludwig, J., Castle, J. C., Schoor, O., Tadmor, A. D., Green, E., Fritsche, J., Meyer, M., Pawlowski, N., Dorner, S., Hoffgaard, F., Rossler, B., Maurer, D., Weinschenk, T., Reinhardt, C., Huber, C., Rammensee, H-G., Singh-Jasuja, H., Sahin, U., Dietrich, P-Y. & Wick, W., Feb 2019, In: Nature. 566, 7745, p. E13

    Research output: Contribution to journalJournal articleResearch

  30. Published

    Actively personalized vaccination trial for newly diagnosed glioblastoma

    Hilf, N., Kuttruff-Coqui, S., Frenzel, K., Bukur, V., Stevanović, S., Gouttefangeas, C., Platten, M., Tabatabai, G., Dutoit, V., van der Burg, S. H., Thor Straten, P., Martínez-Ricarte, F., Ponsati, B., Okada, H., Lassen, U., Admon, A., Ottensmeier, C. H., Ulges, A., Kreiter, S., von Deimling, A., Skardelly, M., Migliorini, D., Kroep, J. R., Idorn, M., Rodon, J., Piró, J., Poulsen, H. S., Shraibman, B., McCann, K., Mendrzyk, R., Löwer, M., Stieglbauer, M., Britten, C. M., Capper, D., Welters, M. J. P., Sahuquillo, J., Kiesel, K., Derhovanessian, E., Rusch, E., Bunse, L., Song, C., Heesch, S., Wagner, C., Kemmer-Brück, A., Ludwig, J., Castle, J. C., Schoor, O., Tadmor, A. D., Green, E., Fritsche, J., Meyer, M., Pawlowski, N., Dorner, S., Hoffgaard, F., Rössler, B., Maurer, D., Weinschenk, T., Reinhardt, C., Huber, C., Rammensee, H-G., Singh-Jasuja, H., Sahin, U., Dietrich, P-Y. & Wick, W., 10 Jan 2019, In: Nature. 565, 7738, p. 240-245 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

  31. Published

    Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma

    Shraibman, B., Barnea, E., Kadosh, D. M., Haimovich, Y., Slobodin, G., Rosner, I., López-Larrea, C., Hilf, N., Kuttruff, S., Song, C., Britten, C., Castle, J., Kreiter, S., Frenzel, K., Tatagiba, M., Tabatabai, G., Dietrich, P-Y., Dutoit, V., Wick, W., Platten, M., Winkler, F., von Deimling, A., Kroep, J., Sahuquillo, J., Martinez-Ricarte, F., Rodon, J., Lassen, U., Ottensmeier, C., van der Burg, S. H., Thor Straten, P., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H-G., Sahin, U., Singh, H. & Admon, A., 1 Jan 2019, In: Molecular & cellular proteomics : MCP. 18, 6, p. 1255-1268 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    A phase Ib/II study of HER3-targeting lumretuzumab in combination with carboplatin and paclitaxel as first-line treatment in patients with advanced or metastatic squamous non-small cell lung cancer

    Cejalvo, J-M., Jacob, W., Fleitas Kanonnikoff, T., Felip, E., Navarro Mendivil, A., Martinez Garcia, M., Taus Garcia, A., Leighl, N., Lassen, U., Mau-Soerensen, M., Adessi, C., Michielin, F., James, I., Ceppi, M., Hasmann, M., Weisser, M. & Cervantes, A., 2019, In: ESMO Open. 4, 4, p. e000532

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published
  34. Published

    Extracranial metastases in glioblastoma-Two case stories

    Schou Nørøxe, D., Regner Michaelsen, S., Broholm, H., Møller, S., Skovgaard Poulsen, H. & Lassen, U., 2019, In: Clinical Case Reports. 7, 2, p. 289-294 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    How I treat NTRK gene fusion-positive cancers

    Lassen, U., 2019, In: ESMO Open. 4, Suppl 2, p. e000612

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published

    Klinisk onkologi

    Lassen, U. & Rahbek Rørth, M., 2019, Medicinsk kompendium. Schaffalitzky de Muckadell, O. B., Hastrup Svendsen, J. & Vilstrup, H. (eds.). 19 ed. København

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  38. Published

    Neoplasi

    Rahbek Rørth, M. & Lassen, U., 2019, Medicinsk kompendium. Schaffalitzky de Muckadell, O. B., Hastrup Svendsen, J. & Vilstrup, H. (eds.). 19 ed. København: Munksgaard

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  39. Published

    Socioeconomic Differences in Referral to Phase I Cancer Clinical Trials: A Danish Matched Cancer Case-Control Study

    Gad, K. T., Johansen, C., Duun-Henriksen, A. K., Krøyer, A., Olsen, M. H., Lassen, U., Mau-Sørensen, M. & Oksberg Dalton, S., 2019, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 13, p. 1111-1119

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2018
  41. Published

    Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer

    Schneeweiss, A., Park-Simon, T-W., Albanell, J., Lassen, U., Cortés, J., Dieras, V., May, M., Schindler, C., Marmé, F., Cejalvo, J. M., Martinez-Garcia, M., Gonzalez, I., Lopez-Martin, J., Welt, A., Levy, C., Joly, F., Michielin, F., Jacob, W., Adessi, C., Moisan, A., Meneses-Lorente, G., Racek, T., James, I., Ceppi, M., Hasmann, M., Weisser, M. & Cervantes, A., Oct 2018, In: Investigational New Drugs. 36, 5, p. 848-859 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published
  43. Published

    Molecular profiling of short-term and long-term surviving patients identifies CD34 mRNA level as prognostic for glioblastoma survival

    Michaelsen, S. R., Urup, T., Olsen, L. R., Broholm, H., Lassen, U. & Poulsen, H. S., May 2018, In: Journal of Neuro-Oncology. 137, 3, p. 533-542 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children

    Drilon, A., Laetsch, T. W., Kummar, S., DuBois, S. G., Lassen, U. N., Demetri, G. D., Nathenson, M., Doebele, R. C., Farago, A. F., Pappo, A. S., Turpin, B., Dowlati, A., Brose, M. S., Mascarenhas, L., Federman, N., Berlin, J., El-Deiry, W. S., Baik, C., Deeken, J., Boni, V., Nagasubramanian, R., Taylor, M., Rudzinski, E. R., Meric-Bernstam, F., Sohal, D. P. S., Ma, P. C., Raez, L. E., Hechtman, J. F., Benayed, R., Ladanyi, M., Tuch, B. B., Ebata, K., Cruickshank, S., Ku, N. C., Cox, M. C., Hawkins, D. S., Hong, D. S. & Hyman, D. M., 22 Feb 2018, In: The New England journal of medicine. 378, 8, p. 731-739 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors

    de Weger, V. A., Goel, S., von Moos, R., Schellens, J. H. M., Mach, N., Tan, E., Anand, S., Scott, J. W. & Lassen, U., 2018, In: Cancer Chemotherapy and Pharmacology. 81, 1, p. 73-80

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published
  47. Published

    A systematic review of targeted agents for non-small cell lung cancer

    Vestergaard, H. H., Christensen, M. R. & Lassen, U. N., 2018, In: Acta oncologica . 57, 2, p. 176-186

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published
  49. Published

    First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer

    Massard, C., Azaro, A., Soria, J-C., Lassen, U., Le Tourneau, C., Sarker, D., Smith, C., Ohnmacht, U., Oakley, G., Patel, B. K. R., Yuen, E. S. M., Benhadji, K. A. & Rodon, J., 2018, In: Annals of Oncology. 29, 9, p. 1911-1917 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Outcome of Bevacizumab Therapy in Patients with Recurrent Glioblastoma Treated with Angiotensin System Inhibitors

    Johansen, M. D., Urup, T., Holst, C. B., Christensen, I. J., Grunnet, K., Lassen, U., Friis, S. & Poulsen, H. S., 2018, In: Cancer Investigation. 36, 9-10, p. 512-519 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Patient information in phase I trials: A systematic review

    Gad, K. T., Lassen, U., Mau-Sørensen, M., Høybye, M. T. & Johansen, C., 2018, In: Psycho-Oncology. 27, 3, p. 768-780

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    TRK Inhibition: A New Tumor-Agnostic Treatment Strategy

    Kummar, S. & Lassen, U. N., 2018, In: Targeted Oncology. 13, 5, p. 545-556 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    VEGF-C Sustains VEGFR2 Activation under Bevacizumab Therapy and Promotes Glioblastoma Maintenance

    Michaelsen, S. R., Staberg, M., Pedersen, H., Jensen, K. E., Majewski, W., Broholm, H., Nedergaard, M. K., Meulengracht, C., Urup, T., Villingshøj, M., Lukacova, S., Skjøth-Rasmussen, J., Brennum, J., Kjær, A., Lassen, U., Stockhausen, M-T., Poulsen, H. S. & Hamerlik, P., 2018, In: Neuro-Oncology. 20, 11, p. 1462-74

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2017
  55. Published
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ID: 31000799