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Rigshospitalet - a part of Copenhagen University Hospital
  1. 2020
  2. Published

    Therapeutic thresholds and mechanisms for primary non-response to infliximab in inflammatory bowel disease

    Buhl, S., Dorn-Rasmussen, M., Brynskov, J., Ainsworth, M. A., Bendtzen, K., Klausen, P. H., Bolstad, N., Warren, D. J. & Steenholdt, C., Aug 2020, In: Scandinavian Journal of Gastroenterology. 55, 8, p. 884-890 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Personalized medicine in rheumatoid arthritis: How immunogenicity impacts use of TNF inhibitors

    Bodio, C., Grossi, C., Pregnolato, F., Favalli, E. G., Biggioggero, M., Marchesoni, A., Murgo, A., Filippini, M., Migliorini, P., Caporali, R., Pellerito, R., Ciccia, F., Sarzi-Puttini, P., Perosa, F., Paolazzi, G., Hollan, I., Bendtzen, K., Meroni, P. L. & Borghi, M. O., May 2020, In: Autoimmunity Reviews. 19, 5, p. 102509

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Pathogenic contribution of the Macrophage migration inhibitory factor family to major depressive disorder and emerging tailored therapeutic approaches

    Petralia, M. C., Mazzon, E., Fagone, P., Basile, M. S., Lenzo, V., Quattropani, M. C., Bendtzen, K. & Nicoletti, F., 15 Feb 2020, In: Journal of Affective Disorders. 263, p. 15-24 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. 2019
  6. Published

    Pattern recognition receptor polymorphisms in early periodontitis

    Leite, F. R. M., Enevold, C., Bendtzen, K., Baelum, V. & López, R., Jun 2019, In: Journal of Periodontology. 90, 6, p. 647-654 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

    Enevold, C., Nielsen, C. H., Molbo, D., Lund, R., Bendtzen, K., Fiehn, N-E. & Holmstrup, P., 2019, In: Scientific Reports. 9, 1, 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

    Fagone, P., Mazzon, E., Bramanti, P., Bendtzen, K. & Nicoletti, F., 5 Sep 2018, In: European Journal of Pharmacology. 834, p. 92-102 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2017
  11. Published

    Biological anti-TNF drugs: immunogenicity underlying treatment failure and adverse events

    Prado, M. S., Bendtzen, K. & Andrade, L. E. C., Sep 2017, In: Expert Opinion on Drug Metabolism and Toxicology. 13, 9, p. 985-995 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?

    Maksimovic-Ivanic, D., Fagone, P., McCubrey, J., Bendtzen, K., Mijatovic, S. & Nicoletti, F., 15 Apr 2017, In: Radiation Oncology Investigations. 140, 8, p. 1713-1726 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Letter: can addition of an immunomodulator really reverse antibody formation and loss of response in patients treated with adalimumab?

    Bendtzen, K. & Steenholdt, C., Mar 2017, In: Alimentary Pharmacology and Therapeutics. 45, 5, p. 759-760 2 p.

    Research output: Contribution to journalLetterResearchpeer-review

  14. Published

    Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis

    Køllgaard, T., Enevold, C., Bendtzen, K., Hansen, P. R., Givskov, M., Holmstrup, P. & Nielsen, C. H., 24 Feb 2017, In: P L o S One. 12, 2, p. e0172773

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2016
  16. Published

    Optimizing Treatment with TNF Inhibitors in Inflammatory Bowel Disease by Monitoring Drug Levels and Antidrug Antibodies

    Steenholdt, C., Bendtzen, K., Brynskov, J. & Ainsworth, M. A., 29 Apr 2016, In: Inflammatory Bowel Diseases. 22, 8, p. 1999-2015

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Circulating Cytokines and Cytokine Receptors in Infliximab Treatment Failure Due to TNF-α Independent Crohn Disease

    Steenholdt, C., Coskun, M., Buhl, S., Bendtzen, K., Ainsworth, M. A., Brynskov, J. & Nielsen, O. H., Apr 2016, In: Medicine (Baltimore). 95, 16, p. e3417

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Anti-Drug Antibodies, Drug Levels, Interleukin-6 and Soluble TNF Receptors in Rheumatoid Arthritis Patients during the First 6 Months of Treatment with Adalimumab or Infliximab: A Descriptive Cohort Study

    Eng, G. P., Bouchelouche, P., Bartels, E. M., Bliddal, H., Bendtzen, K. & Stoltenberg, M., 2016, In: P L o S One. 11, 9, p. e0162316

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published
  20. Published

    Time Course and Clinical Implications of Development of Antibodies Against Adalimumab in Patients With Inflammatory Bowel Disease

    Steenholdt, C., Frederiksen, M. T., Bendtzen, K., Ainsworth, M. A., Thomsen, O. Ø. & Brynskov, J., 2016, In: Journal of Clinical Gastroenterology. 50, 6, p. 483-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2015
  22. Published
  23. Published

    Changes in serum trough levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn's disease

    Steenholdt, C., Bendtzen, K., Brynskov, J., Thomsen, O. Ø., Munck, L. K., Christensen, L. A., Pedersen, G., Kjeldsen, J. & Ainsworth, M. A., Mar 2015, In: Journal of Crohn's & colitis. 9, 3, p. 238-45 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Antibodies to infliximab and adalimumab in patients with rheumatoid arthritis in clinical remission: a cross-sectional study

    Eng, G. P., Bendtzen, K., Bliddal, H., Stoltenberg, M., Szkudlarek, M., Fana, V., Lindegaard, H. M., Omerovic, E., Højgaard, P., Jensen, E. K. & Bouchelouche, P. N., 2015, In: Arthritis. 2015, p. 784825

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Anti-TNF-α therapy for extraintestinal manifestations of inflammatory bowel disease

    Nielsen, O. H., Bendtzen, K. & Pedersen, J., 2015, Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease. Karger, p. 206-13

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  26. Published

    Immunogenicity of Anti-TNF-α Biotherapies: I. Individualized Medicine Based on Immunopharmacological Evidence

    Bendtzen, K., 2015, In: Frontiers in Immunology. 6, p. 152

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Immunogenicity of Anti-TNF-α Biotherapies: II. Clinical Relevance of Methods Used for Anti-Drug Antibody Detection

    Bendtzen, K., 2015, In: Frontiers in Immunology. 6, p. 109

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Individualized Therapy Is a Long-Term Cost-Effective Method Compared to Dose Intensification in Crohn's Disease Patients Failing Infliximab

    Steenholdt, C., Brynskov, J., Thomsen, O. Ø., Munck, L. K., Fallingborg, J., Christensen, L. A., Pedersen, G., Kjeldsen, J., Jacobsen, B. A., Oxholm, A. S., Kjellberg, J., Bendtzen, K. & Ainsworth, M. A., 2015, In: Digestive Diseases and Sciences. 60, 9, p. 2762-70 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Influence of phthalates on in vitro innate and adaptive immune responses

    Hansen, J. F., Nielsen, C. H., Brorson, M. M., Frederiksen, H., Hartoft-Nielsen, M-L., Rasmussen, Å. K., Bendtzen, K. & Feldt-Rasmussen, U., 2015, In: P L o S One. 10, 6, p. e0131168

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2014
  31. Published

    Hypomethylating agent 5-aza-2'-deoxycytidine (DAC) ameliorates multiple sclerosis in mouse models

    Mangano, K., Fagone, P., Bendtzen, K., Meroni, P. L., Quattrocchi, C., Mammana, S., Di Rosa, M., Malaguarnera, L., Coco, M., Magro, G., Di Marco, R. & Nicoletti, F., Dec 2014, In: Journal of Cellular Physiology. 229, 12, p. 1918-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Effect of Melatonin on Human Nighttime Endotoxaemia: Randomized, Double-blinded, Cross-over Study

    Alamili, M., Bendtzen, K., Lykkesfeldt, J., Rosenberg, J. & Gögenur, I., 16 Nov 2014, In: In vivo (Athens, Greece). 28, 6, p. 1057-1063 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Antibodies against infliximab are associated with de novo development of antibodies to adalimumab and therapeutic failure in infliximab-to-adalimumab switchers with IBD

    Frederiksen, M. T., Ainsworth, M. A., Brynskov, J., Thomsen, O. O., Bendtzen, K. & Steenholdt, C., Oct 2014, In: Inflammatory Bowel Diseases. 20, 10, p. 1714-21 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published
  35. Published

    Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus

    Enevold, C., Nielsen, C. H., Jacobsen, R. S., From Hermansen, M-L., Molbo, D., Avlund, K., Bendtzen, K. & Jacobsen, S., Sep 2014, In: Molecular Biology Reports. 41, 9, p. 5755-63 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Clinical implications of measuring drug and anti-drug antibodies by different assays when optimizing infliximab treatment failure in Crohn's disease: post hoc analysis of a randomized controlled trial

    Steenholdt, C., Bendtzen, K., Brynskov, J., Thomsen, O. Ø. & Ainsworth, M. A., Jul 2014, In: The American journal of gastroenterology. 109, 7, p. 1055-64 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model

    Alamili, M., Bendtzen, K., Lykkesfeldt, J., Rosenberg, J. & Gögenur, I., Feb 2014, In: Journal of Critical Care. 29, 1, p. 184.e9-184.e13

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published
  39. Published

    Discontinuation of infliximab therapy in patients with Crohn's disease in sustained complete remission (the STOP IT study): protocol for a double-blind, randomised, placebo-controlled, multicentre trial

    Buhl, S. S., Steenholdt, C., Brynskov, J., Thomsen, O. Ø., Bendtzen, K. & Ainsworth, M. A., 2014, In: B M J Open. 4, 12, p. e005887

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Individualised therapy is more cost-effective than dose intensification in patients with Crohn's disease who lose response to anti-TNF treatment: a randomised, controlled trial

    Steenholdt, C., Brynskov, J., Thomsen, O. Ø., Munck, L. K., Fallingborg, J., Christensen, L. A., Pedersen, G., Kjeldsen, J. C. W., Jacobsen, B. A., Oxholm, A. S., Kjellberg, J., Bendtzen, K. & Ainsworth, M. A., 2014, In: Gut. 4, 63, p. 919 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Pronounced Inflammatory Response to Endotoxaemia during Nighttime: A Randomised Cross-Over Trial

    Alamili, M., Bendtzen, K., Lykkesfeldt, J., Rosenberg, J. & Gögenur, I., 2014, In: P L o S One. 9, 1, p. e87413

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2013
  43. Published

    Commentary: antibodies reacting with the infliximab Fab portion--something new? Authors' reply

    Nielsen, C. H., Steenholdt, C., Palarasah, Y., Bendtzen, K., Teisner, A., Brynskov, J. & Teisner, B., Sep 2013, In: Alimentary Pharmacology and Therapeutics. 38, 5, p. 552-3 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Comparison of techniques for monitoring infliximab and antibodies against infliximab in Crohn's disease

    Steenholdt, C., Ainsworth, M. A., Tovey, M., Klausen, T. W., Thomsen, O. O., Brynskov, J. & Bendtzen, K., Aug 2013, In: Therapeutic Drug Monitoring. 35, 4, p. 530-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Pre-existing IgG antibodies cross-reacting with the Fab region of infliximab predict efficacy and safety of infliximab therapy in inflammatory bowel disease

    Steenholdt, C., Palarasah, Y., Bendtzen, K., Teisner, A., Brynskov, J., Teisner, B. & Nielsen, C. H., Jun 2013, In: Alimentary Pharmacology and Therapeutics. 37, 12, p. 1172-83 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Personalized medicine: theranostics (therapeutics diagnostics) essential for rational use of tumor necrosis factor-alpha antagonists

    Bendtzen, K., Apr 2013, In: Discovery medicine. 15, 83, p. 201-11 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2012
  48. Published

    Anti-TNF-α biotherapies: perspectives for evidence-based personalized medicine

    Bendtzen, K., 2012, In: Immunotherapy. 4, 11, p. 1167-79 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Cytokine responses in infants infected with respiratory syntial virus

    Breindahl, M., Rieneck, K., Nielsen, C. H., Justesen, T., Bendtzen, K. & Müller, K. G., 2012, In: Open Journal of Immunology. 2, 1, p. 40-48 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease

    Steenholdt, C., Enevold, C., Ainsworth, M. A., Brynskov, J., Thomsen, O. Ø. & Bendtzen, K., 2012, In: Alimentary Pharmacology and Therapeutics. 36, 7, p. 650-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published
  52. 2011
  53. Published

    Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production

    Hedegaard, C. J., Sellebjerg, F., Krakauer, M., Hesse, D., Bendtzen, K. & Nielsen, C. H., 1 May 2011, In: Multiple Sclerosis. 17, 5, p. 567-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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