Research
Print page Print page
Switch language
Rigshospitalet - a part of Copenhagen University Hospital
View graph of relations

Expertises

On the basis of my master in molecular biomedicine I have a broad knowledge and experience with the various techniques used for molecular diagnostics.

Main research areas

Reproductive science with focus on molecular mechanisms involved in the female reproductive system.

Current research

The aim of my PhD project is to enhance the knowledge of mechanisms that are essential to female fertility. More specifically the project focuses on regulation of Insulin-like Growth Factor (IGF) activity within female reproductive organs with special emphasis on Pregnancy-Associated Plasma Protein-A (PAPP-A). Single nucleotide polymorphisms (SNPs) in the PAPP-A gene that are associated with adverse pregnancy outcome are analyzed. I will evaluate how these genetic variations affect human ovarian follicular function, and thereby deduce whether genetic variations may or may not influence the female fertility. Evaluation of a possible association between these SNPs and recurrent pregnancy loss will be performed. Further, gene expression levels from isolated stage-specific human follicles will be studied with focus on genes related to the IGF system. Finally, in order to investigate the regulation of IGF signaling in detail an in vitro system using human immature granulosa cells will be established.

Potential conflicts of interest

No conflicts of interest.

ID: 46037536