Research
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Rigshospitalet - a part of Copenhagen University Hospital
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Expertises

Female infertility; preconception counselling. 

Main research areas

Primary research areas are female infertility and preconception counselling. 

Current research

The objectives of this historic prospective cohort study of 260 women aged 25-42 years were: Can AMH predict cumulative pregnancy rates and time to pregnancy (TTP) in women attempting to conceive spontaneously/having an unplanned conception, and is there a lower AMH threshold compatible with spontaneous conception. The study comprised two subcohorts: A) healthcare workers at Rigshospitalet (included: 2008 – 2010), and B) women consulting the Fertility assessment and Counselling Clinic (included: 2011 – 2014), Rigshospitalet, Denmark. Cumulative pregnancy rates and TTP of the two years follow-up were stratified in AMH groups: low AMH: <9.5 pmol/L, intermediate AMH: 9.5–33 pmol/L, high AMH: >33 pmol/L. Cumulative pregnancy rates increased with increasing AMH: 60.1% (low) versus 70.0% (intermediate) versus 78.3% (high AMH) (p=0.03). The highest pregnancy rate (84.1%) was seen in regular cycling women with high AMH. TTP was reduced in women with high AMH compared with intermediate or low AMH (p=0.01). Spontaneous conceptions were observed with AMH concentrations down to 1.2 pmol/L. In conclusion, high AMH, especially in ovulatory women, was associated with higher cumulative pregnancy rates. Nonetheless, TTP reflected a large variation in fecundability within similar AMH concentrations and spontaneous conceptions occurred with AMH down to 1.2 pmol/L.

Potential conflicts of interest

Roche Diagnostics A/S funded the kits for the Elecsys AMH assay, but were not in any way involved in data analysis and preparation of the manuscript. 

ID: 46524979