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Clinical Experimental Research, Department of - a part of Copenhagen University Hospital

Clinical Experimental Research, Department of

Organisational unit: Department

  1. 2021
  2. Published

    Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance

    Sacco, S., Lampl, C., Maassen van den Brink, A., Caponnetto, V., Braschinsky, M., Ducros, A., Little, P., Pozo-Rosich, P., Reuter, U., Ruiz de la Torre, E., Sanchez Del Rio, M., Sinclair, A. J., Martelletti, P., Katsarava, Z., Burden and Attitude to Resistant and Refractory (BARR) Study Group & Edvinsson, L., Dec 2021, In: The Journal of Headache and Pain Online. 22, 1, p. 39 1 p., 39.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

    Christensen, S. L., Rasmussen, R. H., Ernstsen, C., La Cour, S., David, A., Chaker, J., Haanes, K. A., Christensen, S. T., Olesen, J. & Kristensen, D. M., Dec 2021, In: Cephalalgia : an international journal of headache. 41, 14, p. 1413-1426 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    Ovariectomy reduces vasocontractile responses of rat middle cerebral arteries after focal cerebral ischemia

    Rehnström, M., Ahnstedt, H., Krause, D. N., Edvinsson, M. L., Haanes, K. A. & Edvinsson, L., 13 Oct 2021, (E-pub ahead of print) In: Journal of Cardiovascular Pharmacology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP

    Krause, D. N., Warfvinge, K., Haanes, K. A. & Edvinsson, L., Oct 2021, In: Nature reviews. Neurology. 17, 10, p. 621-633 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  6. E-pub ahead of print
  7. Published

    Corticosteroid Resistance in Smokers-A Substudy Analysis of the CORTICO-COP Randomised Controlled Trial

    Sivapalan, P., Bikov, A., Suppli Ulrik, C., Lapperre, T. S., Mathioudakis, A. G., Højberg Lassen, M. C., Grundtvig Skaarup, K., Biering-Sørensen, T., Vestbo, J. & Jensen, J-U. S., 21 Jun 2021, In: Journal of Clinical Medicine. 10, 12, p. 1-11 11 p., 2734.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
  9. Published

    Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

    AMP-T2D-GENES Consortia, 9 Jun 2021, In: Nature Communications. 12, 1, p. 3505 3505.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. E-pub ahead of print
  11. Published
  12. Published
  13. Published

    Identifying New Antimigraine Targets: Lessons from Molecular Biology

    Edvinsson, L. & Haanes, K. A., Apr 2021, In: Trends in Pharmacological Sciences. 42, 4, p. 217-225 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

    Lyhne, M. K., Vegge, A., Povlsen, G. K., Slaaby, R., Kildegaard, J., Pedersen-Bjergaard, U. & Olsen, L. H., 16 Mar 2021, In: Scientific Reports. 11, 1, p. 5983 5983.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Tidligere troede man, migræne skyldtes kvindeligt hysteri

    Barse, M., Olesen, J. & Edvinsson, L., 2021, In: Videnskab.dk [online].

    Research output: Contribution to journalJournal articleCommunication

  16. 2020
  17. Published

    Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects

    Warfvinge, K., Krause, D. N., Maddahi, A., Edvinsson, J. C. A., Edvinsson, L. & Haanes, K. A., Dec 2020, In: Journal of Headache and Pain. 21, 1, p. 131 131.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published
  20. Published

    The effects of CGRP in vascular tissue - Classical vasodilation, shadowed effects and systemic dilemmas

    Sohn, I., Sheykhzade, M., Edvinsson, L. & Sams, A., 15 Aug 2020, In: European Journal of Pharmacology. 881, p. 173205 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published
  22. Published

    Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion

    Edvinsson, L., Grell, A-S. & Warfvinge, K., Jun 2020, In: Journal of Molecular Neuroscience. 70, 6, p. 930-944 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published
  24. Published

    CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles

    Le, T. L., Jagd Grell, A-S., Sheykhzade, M., Warfvinge, K., Edvinsson, L. & Sams, A., 15 May 2020, In: European Journal of Pharmacology. 875, p. 173033

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Cellular distribution of PACAP-38 and PACAP receptors in the rat brain: Relation to migraine activated regions

    Warfvinge, K. & Edvinsson, L., May 2020, In: Cephalalgia : an international journal of headache. 40, 6, p. 527-542 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Ischemic heart failure as a complication of incident acute myocardial infarction: Timing and time trends: A national analysis including 78,814 Danish patients during 2000-2009

    Sulo, G., Sulo, E., Jørgensen, T., Linneberg, A., Prescott, E., Tell, G. S. & Osler, M., May 2020, In: Scandinavian Journal of Public Health. Supplement. 48, 3, p. 294-302 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies

    Haanes, K. A., Edvinsson, L. & Sams, A., 16 Mar 2020, In: The Journal of Headache and Pain Online. 21, 1, p. 26

    Research output: Contribution to journalLetterResearchpeer-review

  28. Published
  29. Published

    The role of purinergic P2Y12 and P2Y13 receptors in ADPβS-induced inhibition of the cardioaccelerator sympathetic drive in pithed rats

    Villanueva-Castillo, B., Rivera-Mancilla, E., Haanes, K. A., MaassenVanDenBrink, A. & Villalón, C. M., Mar 2020, In: Purinergic Signalling. 16, 1, p. 73-84 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Hyperpolarization through ATP-sensitive potassium channels; relevance to migraine pathology

    Haanes, K. A. & Edvinsson, L., 1 Feb 2020, In: Brain. 143, 2, p. e13

    Research output: Contribution to journalLetterResearchpeer-review

  31. Published

    Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache

    Carmine Belin, A., Ran, C. & Edvinsson, L., 6 Jan 2020, In: Brain Sciences. 10, 1, p. 30 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity

    Zhu, J., Pedersen, M. D., Ahmed, L. S., Abdolalizadeh, B., Grell, A-S., Berg, J. O., Thulstrup, P. W., Franzyk, H., Edvinsson, L., Sams, A., Sheykhzade, M. & Hansen, P. R., 2020, In: International Journal of Molecular Sciences. 21, 4, p. E1343 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction

    Bautista-Niño, P. K., Portilla-Fernandez, E., Rubio-Beltrán, E., van der Linden, J. J., de Vries, R., van Veghel, R., de Boer, M., Durik, M., Ridwan, Y., Brandt, R., Essers, J., Menzies, R. I., Thomas, R., de Bruin, A., Duncker, D. J., van Beusekom, H. M. M., Ghanbari, M., Hoeijmakers, J. H. J., Sedlacek, R., Touyz, R. M., Montezano, A. C., van der Pluijm, I., Danser, A. H. J., Haanes, K. A. & Roks, A. J. M., 2020, In: Clinical science (London, England : 1979). 134, 7, p. 727-746 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine

    Warfvinge, K., Krause, D. & Edvinsson, L., 2020, In: The Journal of Headache and Pain Online. 21, 1, p. 10 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The fifth cranial nerve in headaches

    Edvinsson, J. C. A., Viganò, A., Alekseeva, A., Alieva, E., Arruda, R., De Luca, C., D'Ettore, N., Frattale, I., Kurnukhina, M., Macerola, N., Malenkova, E., Maiorova, M., Novikova, A., Řehulka, P., Rapaccini, V., Roshchina, O., Vanderschueren, G., Zvaune, L., Andreou, A. P., Haanes, K. A. & European Headache Federation School of Advanced Studies (EHF-SAS), 2020, In: The Journal of Headache and Pain Online. 21, 1, p. 65

    Research output: Contribution to journalReviewResearchpeer-review

  36. 2019
  37. Published
  38. Published

    C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

    Edvinsson, J. C. A., Warfvinge, K., Krause, D. N., Blixt, F. W., Sheykhzade, M., Edvinsson, L. & Haanes, K. A., 12 Nov 2019, In: The Journal of Headache and Pain Online. 20, 1, p. 105 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology

    Warfvinge, K., Edvinsson, L., Pickering, D. S. & Sheykhzade, M., 1 Nov 2019, In: Pharmacology. 104, 5-6, p. 332-341 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon

    Asferg, C. L., Andersen, U. B., Linneberg, A., Goetze, J. P., Holst, J. J. & Jeppesen, J. L., Nov 2019, In: Diabetic Medicine. 36, 11, p. 1408-1411 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Exploration of physiological and pathophysiological implications of miRNA-143 and miRNA-145 in cerebral arteries

    Christensen, S. T., Johansson, S. E., Warfvinge, K., Braun, T., Boettger, T., Edvinsson, L. & Haanes, K. A., Nov 2019, In: Journal of Cardiovascular Pharmacology. 74, 5, p. 409-419

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Non-eosinophilic severe exacerbations of COPD: what about antibiotics? - Authors' reply

    Sivapalan, P. & Jensen, J. U., Nov 2019, In: The Lancet Respiratory Medicine. 7, 11, p. e34

    Research output: Contribution to journalComment/debateResearchpeer-review

  43. Published

    Regional and socioeconomic variation in survival of melanoma patients in Denmark

    Steding-Jessen, M., Engberg, H., Øster, I., Jensen, J. W., Hölmich, L. R. & Møller, H., Nov 2019, In: Danish Medical Journal. 66, 11, p. A5572

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Exploration of purinergic receptors as potential anti-migraine targets using established pre-clinical migraine models

    Haanes, K. A., Labastida-Ramírez, A., Blixt, F. W., Rubio-Beltrán, E., Dirven, C. M., Danser, A. H., Edvinsson, L. & MaassenVanDenBrink, A., Oct 2019, In: Cephalalgia : an international journal of headache. 39, 11, p. 1421-1434 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Biomarkers of Acute Lung Injury The Individualized Approach: for Phenotyping, Risk Stratification and Treatment Surveillance

    Murray, D. D., Itenov, T. S., Sivapalan, P., Eklöf, J. V., Holm, F. S., Schuetz, P. & Jensen, J. U., 3 Aug 2019, In: Journal of Clinical Medicine. 8, 8

    Research output: Contribution to journalReviewResearchpeer-review

  46. Published

    Does inflammation have a role in migraine?

    Edvinsson, L., Haanes, K. A. & Warfvinge, K., 1 Aug 2019, In: Nature reviews. Neurology. 15, 8, p. 483-490 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Board Walk - July 2019

    Edvinsson, L., 1 Jul 2019, In: Cephalalgia : an international journal of headache. 39, 8, p. 1067-1068 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  48. Published

    Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    CHD Exome+ Consortium, 1 Mar 2019, In: Nature Genetics. 51, 3, p. 452-469 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

    Dallner, O. S., Marinis, J. M., Lu, Y-H., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, T. O., Grarup, N., Linneberg, A., Zhang, Y., Vaughan, R., Loos, R. J. F., Lazar, M. A. & Friedman, J. M., Mar 2019, In: Nature Medicine. 25, 3, p. 507-516 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

    BiomarCaRE Consortium, Mar 2019, In: JACC. Heart failure. 7, 3, p. 204-213 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

    Skaaby, T., Kilpeläinen, T. O., Taylor, A. E., Mahendran, Y., Wong, A., Ahluwalia, T. S., Paternoster, L., Trompet, S., Stott, D. J., Flexeder, C., Zhou, A., Brusselle, G., Sajjad, A., Lahousse, L., Tiemeier, H., Have, C. T., Thuesen, B. H., Kårhus, L. L., Møllehave, L. T., Leth-Møller, K. B., Shabanzadeh, D. M., Gonzalez-Quintela, A., Power, C., Hyppönen, E., Kuh, D., Hardy, R., Meitinger, T., Jukema, J. W., Völker, U., Nauck, M., Völzke, H., Friedrich, N., Bonten, T. N., Noordam, R., Mook-Kanamori, D. O., Tolstrup, J. S., Taube, C., Peters, A., Grallert, H., Strauch, K., Schulz, H., Grarup, N., Hansen, T., Pedersen, O., Burgess, S., Munafò, M. R. & Linneberg, A., 1 Feb 2019, In: Addiction. 114, 2, p. 216-225 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

    Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L., Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W-J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de Las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K-H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H-H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y-D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 Jan 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes

    Niazi, R. K., Sun, J., Have, C. T., Hollensted, M., Linneberg, A., Pedersen, O., Nielsen, J. S., Rungby, J., Grarup, N., Hansen, T. & Gjesing, A. P., 1 Jan 2019, In: PLoS One. 14, 1, p. e0210114 e0210114.

    Research output: Contribution to journalJournal articleResearchpeer-review

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