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Why do normal children have acromegalic levels of IGF-I during puberty?

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@article{9016f96ce0364eeab89a22add84dbded,
title = "Why do normal children have acromegalic levels of IGF-I during puberty?",
abstract = "CONTEXT: The rapid pubertal height growth is unique to humans, but why do we have it? Although the spurt contributes 13-15{\%} to the final adult height, we hypothesize that the biological significance of the high acromegalic levels of GH and IGF-I which are behind the pubertal growth spurt may primarily be to stimulate reproductive organs.EVIDENCE SYNTHESIS: Animal data demonstrate that adult Igf1 and Igf2 gene knockout mice that survive show a dramatic reduction in the sizes of reproductive organs, and are infertile. In humans, case reports of mutations in genes affecting the GH-IGF axis and growth (GH, GHRH, GH-R, STAT5b, IGF-I, IGF-II, IGF-1R, PAPPA2) are also characterized by delayed pubertal onset and micro-penis. Furthermore, GH treatment tend to normalize penile size in GHD patients. We believe that endocrine effects of high IGF-I levels may be needed for transition of the sexual organs, including secondary sex characteristics from the 'dormant' stages of childhood into full functioning reproductive systems.It is noteworthy that peak IGF-I levels on average occur two years after peak height growth velocity suggesting other reasons than longitudinal growth for the high IGF-I levels. and remain high in years after the height spurt, when the reproductive systems become fully functional.CONCLUSION: We suggest that serum levels of IGF-I should be watched in children with poor development of sexual organs, although it remains to be investigated whether GH in some cases should be added to sex steroids in management of hypogonadism in pubertal children, e.g. in boys with micro-penis.",
author = "Anders Juul and Skakkeb{\ae}k, {Niels E}",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
month = "3",
day = "21",
doi = "10.1210/jc.2018-02099",
language = "English",
volume = "104",
pages = "2770--2776",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "7",

}

RIS

TY - JOUR

T1 - Why do normal children have acromegalic levels of IGF-I during puberty?

AU - Juul, Anders

AU - Skakkebæk, Niels E

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/3/21

Y1 - 2019/3/21

N2 - CONTEXT: The rapid pubertal height growth is unique to humans, but why do we have it? Although the spurt contributes 13-15% to the final adult height, we hypothesize that the biological significance of the high acromegalic levels of GH and IGF-I which are behind the pubertal growth spurt may primarily be to stimulate reproductive organs.EVIDENCE SYNTHESIS: Animal data demonstrate that adult Igf1 and Igf2 gene knockout mice that survive show a dramatic reduction in the sizes of reproductive organs, and are infertile. In humans, case reports of mutations in genes affecting the GH-IGF axis and growth (GH, GHRH, GH-R, STAT5b, IGF-I, IGF-II, IGF-1R, PAPPA2) are also characterized by delayed pubertal onset and micro-penis. Furthermore, GH treatment tend to normalize penile size in GHD patients. We believe that endocrine effects of high IGF-I levels may be needed for transition of the sexual organs, including secondary sex characteristics from the 'dormant' stages of childhood into full functioning reproductive systems.It is noteworthy that peak IGF-I levels on average occur two years after peak height growth velocity suggesting other reasons than longitudinal growth for the high IGF-I levels. and remain high in years after the height spurt, when the reproductive systems become fully functional.CONCLUSION: We suggest that serum levels of IGF-I should be watched in children with poor development of sexual organs, although it remains to be investigated whether GH in some cases should be added to sex steroids in management of hypogonadism in pubertal children, e.g. in boys with micro-penis.

AB - CONTEXT: The rapid pubertal height growth is unique to humans, but why do we have it? Although the spurt contributes 13-15% to the final adult height, we hypothesize that the biological significance of the high acromegalic levels of GH and IGF-I which are behind the pubertal growth spurt may primarily be to stimulate reproductive organs.EVIDENCE SYNTHESIS: Animal data demonstrate that adult Igf1 and Igf2 gene knockout mice that survive show a dramatic reduction in the sizes of reproductive organs, and are infertile. In humans, case reports of mutations in genes affecting the GH-IGF axis and growth (GH, GHRH, GH-R, STAT5b, IGF-I, IGF-II, IGF-1R, PAPPA2) are also characterized by delayed pubertal onset and micro-penis. Furthermore, GH treatment tend to normalize penile size in GHD patients. We believe that endocrine effects of high IGF-I levels may be needed for transition of the sexual organs, including secondary sex characteristics from the 'dormant' stages of childhood into full functioning reproductive systems.It is noteworthy that peak IGF-I levels on average occur two years after peak height growth velocity suggesting other reasons than longitudinal growth for the high IGF-I levels. and remain high in years after the height spurt, when the reproductive systems become fully functional.CONCLUSION: We suggest that serum levels of IGF-I should be watched in children with poor development of sexual organs, although it remains to be investigated whether GH in some cases should be added to sex steroids in management of hypogonadism in pubertal children, e.g. in boys with micro-penis.

UR - http://www.scopus.com/inward/record.url?scp=85066857092&partnerID=8YFLogxK

U2 - 10.1210/jc.2018-02099

DO - 10.1210/jc.2018-02099

M3 - Review

VL - 104

SP - 2770

EP - 2776

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

M1 - jcem_201802099

ER -

ID: 56782560