Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Vitamin D levels and the risk of prostate cancer and prostate cancer mortality

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mortality from cardiovascular disease in women with breast cancer - a nationwide registry study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of human papillomavirus in sinonasal cancer-a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Factors associated with melanoma-related limb lymphoedema

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk of Depression After Radical Prostatectomy-A Nationwide Registry-based Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Vitamin D has a role in bone turnover and potentially bone-metastatic spread of prostate cancer (PCa). The aim of this observational study was to address the association between levels of serum vitamin D, diagnosis of PCa and subsequent mortality in men who underwent a biopsy of the prostate.

METHODS: All men who underwent prostatic biopsy in the Danish PCa Registry (DaPCaR) and who had a serum vitamin D measurement during the period 2004 to 2010 (n = 4,065) were identified. Men were categorized by clinical cut-offs based on seasonally adjusted serum vitamin D levels in <25 (deficient), 25-50 (insufficient), 50-75 (sufficient) and >75 nmol/L (high) serum vitamin D. Logistic regression model for association between vitamin D and risk of PCa diagnosis and multivariate survival analyses were applied.

RESULTS: No association between serum vitamin D and risk of PCa was found. Overall survival was lowest for serum vitamin D deficiency and a significantly higher PCa specific mortality (HR: 2.37, 95%CI: 1.45-3.90, p < .001) and other cause mortality (HR: 2.08, 95%CI: 1.33-3.24, p = .001) was found for PCa patients with serum vitamin D deficiency compared to serum vitamin D sufficiency.

CONCLUSION: No association was found between serum vitamin D categories and risk of PCa in men who underwent biopsy of the prostate. Men with PCa and serum vitamin D deficiency had a higher overall and PCa specific mortality compared to men with a sufficient level of serum vitamin D.

OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind60
Udgave nummer3
Sider (fra-til)316-322
Antal sider7
ISSN0284-186X
DOI
StatusUdgivet - mar. 2021

ID: 61115398