Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Vitamin D levels and Cancer Incidence in 217.244 individuals from Primary Health Care in Denmark

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Common gene variants within 3'-untranslated regions as modulators of multiple myeloma risk and survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: The impact of the gut microbiota

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of specific types of ovarian cancer after borderline ovarian tumors in Denmark: A nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Risk of cervical intraepithelial neoplasia grade 2 or worse after conization in relation to HPV vaccination status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Republished: Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Does vascular endothelial dysfunction play a role in physical frailty and sarcopenia? A systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. RANKL regulates male reproductive function

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The calcium-sensing receptor is essential for calcium and bicarbonate sensitivity in human spermatozoa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Fie Juhl Vojdeman
  • Christian Medom Madsen
  • Kirsten Frederiksen
  • Darshana Durup
  • Anja Olsen
  • Louise Hansen
  • Anne-Marie Heegaard
  • Bent Lind
  • Anne Tjønneland
  • Henrik Løvendahl Jørgensen
  • Peter Schwarz
Vis graf over relationer

Vitamin D has been linked to cancer development in both pre-clinical and epidemiological studies. Our study examines the association between serum levels of vitamin D and cancer incidence in the Capital Region of Denmark. Individuals who had vitamin D analyzed at The Copenhagen General Practitioners Laboratory between April 2004 and January 2010 were linked to Danish registries with end of follow-up date at Dec 31st 2014, excluding individuals with pre-existing cancer. Cox regression models adjusted for age in one-year intervals, sex, month of sampling, and Charlson Comorbidity Index were applied. The study population of 217,244 individuals had a median vitamin D level of 46 nmol/L (IQR 27–67 nmol/L). Non-melanoma skin cancer was the most frequent form of cancer, followed by breast-, lung-, and prostate cancers. No associations were found between increments of 10 nmol/L vitamin D and incidence of breast, colorectal, urinary, ovary or corpus uteri cancer. However, higher levels of vitamin D were associated with higher incidence of non-melanoma (HR 1.09 [1.09–1.1]) and melanoma skin cancer (HR 1.1 [1.08–1.13]) as well as prostate (HR 1.05 [1.03–1.07]) and hematological cancers (HR 1.03 [1.01–1.06]), but with lower incidence of lung cancer (HR 0.95 [0.93–0.97]). In our study, vitamin D levels are not associated with the incidence of several major cancer types, but higher levels are significantly associated with a higher incidence of skin, prostate, and hematological cancers as well as a lower incidence of lung cancer. These results do not support an overall protective effect against cancer by vitamin D.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind145
Udgave nummer2
Sider (fra-til)338-346
ISSN0020-7136
DOI
StatusUdgivet - 15 jul. 2019

ID: 56118237