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Vitamin D and sex steroid production in men with normal or impaired Leydig cell function

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  1. An evaluation of total 25-hydroxyvitamin D assay standardization: Where are we today?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Possible influence of vitamin D on male reproduction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Influence of vitamin D on cisplatin sensitivity in testicular germ cell cancer-derived cell lines and in a NTera2 xenograft model

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  1. Calcium transport in male reproduction is possibly influenced by vitamin D and CaSR

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Accelerated loss of oogonia and impaired folliculogenesis in females with Turner syndrome start during early fetal development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain

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Vis graf over relationer

Production of testosterone is under tight control by human chorion gonadotropin (hCG) during fetal life and luteinizing hormone (LH) in adulthood. Several animal and human studies have linked vitamin D status with sex steroid production although it is not clear whether there exist a direct or indirect involvement in androgen production. Few studies have investigated this crosslink in young healthy men and putative direct or synergistic effect of activated vitamin D (1,25(OH) 2D 3) and LH/hCG on sex steroid production in vitro. Here, we present cross-sectional data from 300 young men and 41 hCG-stimulated men with impaired Leydig cell function combined with data from an ex vivo culture of human testicular tissue exposed to 1,25(OH) 2D 3 alone or in combination with hCG. Serum 25-OHD was positively associated with SHBG (β:0.002; p = 0.023) and testosterone/estradiol-ratio (β:0.001; p = 0.039), and inversely associated with free testosterone (%) (free testosterone/total testosterone) (β:-0.002; p = 0.016) in young men. Vitamin D deficient men had higher total and free estradiol concentrations than men with higher vitamin D status (19% and 18%, respectively; p < 0.01). Interestingly, men with impaired Leydig cell function and vitamin D deficiency had a significantly lower hCG-mediated increase in total and free testosterone compared with vitamin D sufficient men (p < 0.05). Accordingly, testicular tissue exposed to 100 nM 1,25(OH) 2D 3 had a 15% higher testosterone release into the media compared with vehicle treated specimens (p = 0.030). In conclusion, vitamin D deficiency is associated with lower testosterone/estradiol ratio in young men and lower Leydig cell sensitivity after hCG-stimulation in men with impaired gonadal function. The significant effect of 1,25(OH) 2D 3 on testosterone production in a human testis model supports that the stimulatory effect at least in part may be direct. Larger placebo-controlled studies are needed to determine whether vitamin D supplementation can influence testosterone production.

OriginalsprogEngelsk
Artikelnummer105589
TidsskriftThe Journal of steroid biochemistry and molecular biology
Vol/bind199
Sider (fra-til)105589
Antal sider8
ISSN0960-0760
DOI
StatusUdgivet - maj 2020

ID: 59056489