Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Validation of diffuse correlation spectroscopy against O-15-water PET for regional cerebral blood flow measurement in neonatal piglets

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. False positive rates in positron emission tomography (PET) voxelwise analyses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. How to safeguard the brain of extremely preterm infants?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Central data monitoring in the multicentre randomised SafeBoosC-III trial - a pragmatic approach

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The effect of early probiotic exposure on the preterm infant gut microbiome development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Extremely Preterm Infant Admissions Within the SafeBoosC-III Consortium During the COVID-19 Lockdown

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Aerosol generation by respiratory support of neonates may be low

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

Diffuse correlation spectroscopy (DCS) can non-invasively and continuously asses regional cerebral blood flow (rCBF) at the cot-side by measuring a blood flow index (BFI) in non-traditional units of cm 2/s. We have validated DCS against positron emission tomography using 15O-labeled water ( 15O-water PET) in a piglet model allowing us to derive a conversion formula for BFI to rCBF in conventional units (ml/100g/min). Neonatal piglets were continuously monitored by the BabyLux device integrating DCS and time resolved near infrared spectroscopy (TRS) while acquiring 15O-water PET scans at baseline, after injection of acetazolamide and during induced hypoxic episodes. BFI by DCS was highly correlated with rCBF (R = 0.94, p  < 0.001) by PET. A scaling factor of 0.89 (limits of agreement for individual measurement: 0.56, 1.39)×10 9× (ml/100g/min)/(cm 2/s) was used to derive baseline rCBF from baseline BFI measurements of another group of piglets and of healthy newborn infants showing an agreement with expected values. These results pave the way towards non-invasive, cot-side absolute CBF measurements by DCS on neonates.

OriginalsprogEngelsk
TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Vol/bind40
Udgave nummer10
Sider (fra-til)2055-2065
Antal sider11
ISSN0271-678X
DOI
StatusUdgivet - okt. 2020

ID: 59411197