Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Plasma TNF binding capacity in patients with juvenile idiopathic arthritis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pattern recognition receptor polymorphisms in early periodontitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6.
OriginalsprogEngelsk
TidsskriftInternational Immunopharmacology
Vol/bind7
Udgave nummer13
Sider (fra-til)1704-13
Antal sider10
ISSN1567-5769
DOI
StatusUdgivet - 15 dec. 2007

ID: 32256458