Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

UV light assisted antibiotics for eradication of in vitro biofilms

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Collagen turnover profiles in chronic kidney disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. An Equine Wound Model to Study Effects of Bacterial Aggregates on Wound Healing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

The overuse of antibiotics is accelerating the bacterial resistance, and therefore there is a need to reduce the amount of antibiotics used for treatment. Here, we demonstrate in vitro that specific wavelengths in a narrow range around 296 nm are able to eradicate bacteria in the biofilm state (grown for 24 hours) more effectively, than antibiotics and the combination of irradiation and antibiotics is even better, introducing a novel concept light assisted antibiotics. The investigated wavelength range was 249 nm to 338 nm with an approximate step of 5 nm. The novel concept that consists of a UV irradiation treatment followed by a tobramycin treatment can significantly reduce the amount of antibiotics needed for eradicating mature bacterial biofilms. The efficiency of the proposed light assisted antibiotics method was compared to combinatory antibiotic treatment and highly concentrated antibiotic monotherapy. The eradication efficacies, on mature biofilms, achieved by light assisted antibiotic and by the antibiotic monotherapy at approximately 10-fold higher concentration, were equivalent. The present achievement could motivate the development of light assisted antibiotic treatments for treating infections.

OriginalsprogEngelsk
TidsskriftScientific Reports
Vol/bind8
Udgave nummer1
Sider (fra-til)16360
ISSN2045-2322
DOI
StatusUdgivet - 5 nov. 2018

ID: 56273305