Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Urinary bisphenol A concentrations are associated with reproductive parameters in young men

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Road traffic noise and markers of adiposity in the Danish nurse cohort: A cross sectional study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Long-term testosterone undecanoate treatment in the elderly testosterone deficient male - an observational cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Vitamin D supplementation improves fasting insulin levels and HDL cholesterol in infertile men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Presence of SARS-CoV-2 in semen and the impact of COVID-19 on the male reproductive system

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Are worldwide sperm counts declining?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Behandling af mandlig infertilitet

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Evdochia Adoamnei
  • Jaime Mendiola
  • Fernando Vela-Soria
  • Mariana F Fernández
  • Nicolás Olea
  • Niels Jørgensen
  • Shanna H Swan
  • Alberto M Torres-Cantero
Vis graf over relationer

Bisphenol A (BPA) is a pervasive environmental toxicant with known reproductive effects on sperm parameters and hormone levels. Several observational studies have investigated the associations between BPA exposure and male reproductive function, but findings are inconsistent. The objective of this study was to assess the associations between urinary BPA concentrations and semen quality and reproductive hormone levels in a cross-sectional study with 215 healthy young university students (18-23 years old), investigated between 2010 and 2011 in Southern Spain (Murcia Region). All subjects provided urine, blood serum and semen samples on a single day. Urinary BPA concentrations were measured by dispersive liquid-liquid microextraction and ultra-high performance liquid chromatography with tandem mass spectrometry detection. Semen quality was evaluated by measuring volume, concentration, motility, morphology and total sperm count (TSC). Serum samples were analyzed for reproductive hormones, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, inhibin B and estradiol. Relationships between urinary BPA concentrations and semen quality parameters and reproductive hormone levels were examined using linear regression, adjusting for potential confounders and covariates. Ninety-five percent of the men had detectable urinary BPA concentrations with unadjusted median (5th-95th) of 2.8 (0.16-11.5) ng/mL. After adjustment for important covariates, there was a significant positive association between urinary BPA concentrations and serum LH levels (β = 0.07, 95%CI: 0.02;0.12, p-value < 0.01). Urinary BPA concentration was also significantly and inversely associated with sperm concentration (β = - 0.04, 95%CI: - 0.07;- 0.02, p-value < 0.01) and TSC (β = - 0.05, 95%CI: - 0.08;- 0.02, p-value < 0.01). No significant associations were found between BPA and other semen parameters or reproductive hormone levels. Our results support the hypothesis that BPA exposure may be associated with a reduction in Leydig cell capacity (increased LH levels) and decreased sperm counts in young men.

OriginalsprogEngelsk
TidsskriftEnvironmental Research
Vol/bind161
Sider (fra-til)122-128
Antal sider7
ISSN0013-9351
DOI
StatusUdgivet - feb. 2018

ID: 52170836