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Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  2. Investigation of cortical thickness and volume during spontaneous attacks of migraine without aura: a 3-Tesla MRI study

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  3. Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020

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  4. Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis

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  1. Paracetamol use during pregnancy - a call for precautionary action

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  2. Poor social support and loneliness in chronic headache: Prevalence and effect modifiers

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  3. Health-related quality of life in tension-type headache: a population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Guidelines of the International Headache Society for clinical trials with neuromodulation devices for the treatment of migraine

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Vis graf over relationer

BACKGROUND: Obesity confers adverse effects to every system in the body including the central nervous system. Obesity is associated with both migraine and idiopathic intracranial hypertension (IIH). The mechanisms underlying the association between obesity and these headache diseases remain unclear.

METHODS: We conducted a narrative review of the evidence in both humans and rodents, for the putative mechanisms underlying the link between obesity, migraine and IIH.

RESULTS: Truncal adiposity, a key feature of obesity, is associated with increased migraine morbidity and disability through increased headache severity, frequency and more severe cutaneous allodynia. Obesity may also increase intracranial pressure and could contribute to headache morbidity in migraine and be causative in IIH headache. Weight loss can improve both migraine and IIH headache. Preclinical research highlights that obesity increases the sensitivity of the trigeminovascular system to noxious stimuli including inflammatory stimuli, but the underlying molecular mechanisms remain unelucidated.

CONCLUSIONS: This review highlights that at the epidemiological and clinical level, obesity increases morbidity in migraine and IIH headache, where weight loss can improve headache morbidity. However, further research is required to understand the molecular underpinnings of obesity related headache in order to generate novel treatments.

OriginalsprogEngelsk
Artikelnummer123
TidsskriftJournal of Headache and Pain
Vol/bind22
Udgave nummer1
ISSN1129-2377
DOI
StatusUdgivet - 2021

Bibliografisk note

© 2021. The Author(s).

ID: 68392068