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Ultraviolet radiation drives mutations in a subset of mucosal melanomas

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Mundra, PA, Dhomen, N, Rodrigues, M, Mikkelsen, LH, Cassoux, N, Brooks, K, Valpione, S, Reis-Filho, JS, Heegaard, S, Stern, M-H, Roman-Roman, S & Marais, R 2021, 'Ultraviolet radiation drives mutations in a subset of mucosal melanomas', Nature Communications, bind 12, nr. 1, 259, s. 259. https://doi.org/10.1038/s41467-020-20432-5

APA

Mundra, P. A., Dhomen, N., Rodrigues, M., Mikkelsen, L. H., Cassoux, N., Brooks, K., Valpione, S., Reis-Filho, J. S., Heegaard, S., Stern, M-H., Roman-Roman, S., & Marais, R. (2021). Ultraviolet radiation drives mutations in a subset of mucosal melanomas. Nature Communications, 12(1), 259. [259]. https://doi.org/10.1038/s41467-020-20432-5

CBE

Mundra PA, Dhomen N, Rodrigues M, Mikkelsen LH, Cassoux N, Brooks K, Valpione S, Reis-Filho JS, Heegaard S, Stern M-H, Roman-Roman S, Marais R. 2021. Ultraviolet radiation drives mutations in a subset of mucosal melanomas. Nature Communications. 12(1):259. https://doi.org/10.1038/s41467-020-20432-5

MLA

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Author

Mundra, Piyushkumar A ; Dhomen, Nathalie ; Rodrigues, Manuel ; Mikkelsen, Lauge Hjorth ; Cassoux, Nathalie ; Brooks, Kelly ; Valpione, Sara ; Reis-Filho, Jorge S ; Heegaard, Steffen ; Stern, Marc-Henri ; Roman-Roman, Sergio ; Marais, Richard. / Ultraviolet radiation drives mutations in a subset of mucosal melanomas. I: Nature Communications. 2021 ; Bind 12, Nr. 1. s. 259.

Bibtex

@article{159658a00e614a3a9743b7be3ee6e1c1,
title = "Ultraviolet radiation drives mutations in a subset of mucosal melanomas",
abstract = "Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.",
keywords = "Adult, Aged, Aged, 80 and over, Conjunctiva/pathology, DNA Damage, Female, Genome, Human, Humans, Male, Melanoma/genetics, Middle Aged, Mucous Membrane/pathology, Mutation/genetics, Skin Neoplasms/genetics, Ultraviolet Rays",
author = "Mundra, {Piyushkumar A} and Nathalie Dhomen and Manuel Rodrigues and Mikkelsen, {Lauge Hjorth} and Nathalie Cassoux and Kelly Brooks and Sara Valpione and Reis-Filho, {Jorge S} and Steffen Heegaard and Marc-Henri Stern and Sergio Roman-Roman and Richard Marais",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = dec,
doi = "10.1038/s41467-020-20432-5",
language = "English",
volume = "12",
pages = "259",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Ultraviolet radiation drives mutations in a subset of mucosal melanomas

AU - Mundra, Piyushkumar A

AU - Dhomen, Nathalie

AU - Rodrigues, Manuel

AU - Mikkelsen, Lauge Hjorth

AU - Cassoux, Nathalie

AU - Brooks, Kelly

AU - Valpione, Sara

AU - Reis-Filho, Jorge S

AU - Heegaard, Steffen

AU - Stern, Marc-Henri

AU - Roman-Roman, Sergio

AU - Marais, Richard

N1 - Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12

Y1 - 2021/12

N2 - Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.

AB - Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Conjunctiva/pathology

KW - DNA Damage

KW - Female

KW - Genome, Human

KW - Humans

KW - Male

KW - Melanoma/genetics

KW - Middle Aged

KW - Mucous Membrane/pathology

KW - Mutation/genetics

KW - Skin Neoplasms/genetics

KW - Ultraviolet Rays

UR - http://www.scopus.com/inward/record.url?scp=85099194063&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-20432-5

DO - 10.1038/s41467-020-20432-5

M3 - Journal article

C2 - 33431815

VL - 12

SP - 259

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 259

ER -

ID: 61960171